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Document ID (ISN)103860
CIS number 05-65
ISSN - Serial title 0019-8366 - Industrial Health
Year 2004
Convention or series no.
Author(s) Buranatrevedh S.
Title Cancer risk assessment of toxaphene
Bibliographic information July 2004, Vol.42, No.3, p.321-327. 5 ref.
Internet access [in English]
Abstract The cancer risk of toxaphene was assessed using the four steps of risk assessment proposed by the United States National Academy of Sciences/National Research Council (NAS/NRC) namely hazard identification, dose-response relationship, exposure assessment and risk characterization. Toxaphene was the most heavily used insecticide in many parts of the world before it was banned in 1982. It increased the incidence of neoplasms of the liver and uterus in mice and the incidence of neoplasms of endocrine organs, thyroid, pituitary, adrenal, mammary glands, and reproductive systems in rats. The slope factor in studies on mice and rats is 0.8557 (mg/kg/day)-1. Lifetime average daily dose of toxaphene from ambient air, surface water, soil and fish were 1.08x10-6, 5.71x10-6, 3.43x10-7, and 7.96x10-5 mg/kg/day, respectively. Cancer risk of toxaphene for average exposure was 7.42x10-5. This study indicates that toxaphene might present a carcinogenic risk to humans.
Descriptors (primary) toxaphene; carcinogenic effects; hazard evaluation; insecticides
Descriptors (secondary) exposure evaluation; ecotoxicology; neoplasms; dose-response relationship; animal experiments
Document type D - Periodical articles
Country / State or ProvinceThailand
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Risk evaluation
Halogenated hydrocarbons
Agricultural chemicals