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Document ID (ISN)103859
CIS number 05-158
ISSN - Serial title 0019-8366 - Industrial Health
Year 2004
Convention or series no.
Author(s) Kurihara N., Wada O.
Title Silicosis and smoking strongly increase lung cancer risk in silica-exposed workers
Bibliographic information July 2004, Vol.42, No.3, p.303-314. Illus. 67 ref.
Internet access [in English]
Abstract It remains controversial whether silica is a human lung carcinogen. A literature search was performed on papers published from 1966-2001 which epidemiologically reported on the relationship between silica/silicosis and lung cancer. Papers which did not exclude the effects of asbestos and radioactive materials including radon were removed. Based on the selected papers, the lung cancer risks from silica, silicosis and non-silicosis with exposure to silica were summarized by meta-analysis. The pooled relative risks were 1.32 for silica, 2.37 for silicosis and 0.96 for non-silicosis with exposure to silica. Since some papers on silica did not exclude silicosis, the risk due to silica itself may be smaller than 1.32. It was less possible that silica exposure directly increases lung cancer risk. On the other hand, the relative risk of 2.37 for silicosis suggested that silicosis increases lung cancer risk. The meta-analysis also revealed that cigarette smoking strongly increased the lung cancer risk in silicotic patients (relative risk, 4.47).
Descriptors (primary) silica; silicosis; lung cancer; smoking
Descriptors (secondary) literature survey; hazard evaluation; epidemiology
Document type D - Periodical articles
Country / State or ProvinceJapan
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)