| Document ID (ISN) | 103857 |
| CIS number |
05-64 |
| ISSN - Serial title |
1076-2752 - Journal of Occupational and Environmental Medicine |
| Year |
2004 |
| Convention or series no. |
|
| Author(s) |
Hsiao T.J., Wang J.D., Yang P.M., Yang P.C., Cheng T.J. |
| Title |
Liver fibrosis in asymptomatic polyvinyl chloride workers |
| Bibliographic information |
Sep. 2004, Vol.46, No.9, p.962-966. 20 ref. |
| Abstract |
This study was designed to determine whether vinyl chloride monomer (VCM) exposure is associated with liver fibrosis. 347 workers with occupational exposure to VCM were systemically examined using liver ultrasonography and routine liver function tests. Vinyl chloride monomer cumulative dose (ppm-month) was estimated by summing the products of air VCM concentration levels and months of employment. Liver fibrosis was defined in subjects with precirrhosis and cirrhosis of the liver diagnosed using ultrasonography. Significantly increased risks of developing liver fibrosis were found in workers who had a history of high exposure jobs (odds ratio 5.5) when compared with workers without such a history. It is concluded that there is an increased risk of developing liver fibrosis in PVC workers with high exposures to VCM. |
| Descriptors (primary) |
vinyl chloride; plastics industry; liver fibrosis |
| Descriptors (secondary) |
cirrhosis; hazard evaluation; ultrasonic examinations; long-term exposure; liver function tests; exposure evaluation |
| Document type |
D - Periodical articles |
| Country / State or Province | Taiwan (China) |
| Subject(s) |
Occupational pathology
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
Occupational medicine, epidemiology
|
| Browse category(ies) |
Chemical industry
Liver diseases
Halogenated hydrocarbons
Plastics industry
|
