|Document ID (ISN)||103547|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Hsieh H.I., Wang J.D., Chen P.C., Cheng T.J.
||Synergistic effect of hepatitis virus infection and occupational exposures to vinyl chloride monomer and ethylene dichloride on serum aminotransferase activity
||Oct. 2003, Vol.60, No.10, p.774-778. Illus. 25 ref.
||This study examines the synergistic effect of occupational chemical exposure and hepatitis virus infection on serum aminotransferase activity. A total of 568 male workers who were employed in five polyvinyl chloride and four vinyl chloride monomer (VCM) manufacturing factories were studied. Workers were classified into high, moderate and low exposure groups according to their level of exposure to chemical mixtures. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and anti-hepatitis C antibody were assayed. Hepatitis virus infection and increased body mass index were associated with abnormal serum aminotransferase activity. In workers with hepatitis virus infection, those with high exposure had a higher prevalence of abnormal AST and ALT compared to low exposure; among those without hepatitis virus infection, no significant differences of prevalence of abnormal AST and ALT were found between different chemical exposure groups. There was a significant trend of increasing risks of increased AST and ALT in moderate and high exposure groups with hepatitis virus infection. Such a synergistic effect was more prominent among HBeAg-positive workers. It is concluded that mixed exposures to 1,2-ethylene dichloride and VCM have a positive synergistic effect with hepatitis virus infection on liver damage.
||1,1-dichloroethane; vinyl chloride; synergism; infectious hepatitis; transaminases
||chemical industry; 1,2-dichloroethylene; antigens; frequency rates; hazard evaluation; statistical evaluation; enzyme activity
||D - Periodical articles
|Country / State or Province||Taiwan (China)|
||Toxic and dangerous substances
|Broad subject area(s)
Bacterial and parasitic diseases
Viral diseases (other than aids)