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Document ID (ISN)103547
CIS number 04-621
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2003
Convention or series no.
Author(s) Hsieh H.I., Wang J.D., Chen P.C., Cheng T.J.
Title Synergistic effect of hepatitis virus infection and occupational exposures to vinyl chloride monomer and ethylene dichloride on serum aminotransferase activity
Bibliographic information Oct. 2003, Vol.60, No.10, p.774-778. Illus. 25 ref.
Abstract This study examines the synergistic effect of occupational chemical exposure and hepatitis virus infection on serum aminotransferase activity. A total of 568 male workers who were employed in five polyvinyl chloride and four vinyl chloride monomer (VCM) manufacturing factories were studied. Workers were classified into high, moderate and low exposure groups according to their level of exposure to chemical mixtures. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and anti-hepatitis C antibody were assayed. Hepatitis virus infection and increased body mass index were associated with abnormal serum aminotransferase activity. In workers with hepatitis virus infection, those with high exposure had a higher prevalence of abnormal AST and ALT compared to low exposure; among those without hepatitis virus infection, no significant differences of prevalence of abnormal AST and ALT were found between different chemical exposure groups. There was a significant trend of increasing risks of increased AST and ALT in moderate and high exposure groups with hepatitis virus infection. Such a synergistic effect was more prominent among HBeAg-positive workers. It is concluded that mixed exposures to 1,2-ethylene dichloride and VCM have a positive synergistic effect with hepatitis virus infection on liver damage.
Descriptors (primary) 1,1-dichloroethane; vinyl chloride; synergism; infectious hepatitis; transaminases
Descriptors (secondary) chemical industry; 1,2-dichloroethylene; antigens; frequency rates; hazard evaluation; statistical evaluation; enzyme activity
Document type D - Periodical articles
Country / State or ProvinceTaiwan (China)
Subject(s) Toxic and dangerous substances
Broad subject area(s) Biological hazards
Chemical safety
Browse category(ies) Liver diseases
Halogenated hydrocarbons
Bacterial and parasitic diseases
Viral diseases (other than aids)