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Document ID (ISN)103545
CIS number 04-576
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2003
Convention or series no.
Author(s) Joffe M., Bisanti L., Apostoli P., Kiss P., Dale A., Roeleveld N., Lindbohm M.L., Sallmén M., Vanhoorne M., Bonde J.P.
Title Time to pregnancy and occupational lead exposure
Bibliographic information Oct. 2003, Vol.60, No.10, p.752-758. Illus. 35 ref.
Abstract Lead exposure is known to be harmful to the male reproductive system, including impairment of fertility. However, it is unclear whether currently existing low levels of exposure have this effect. This study retrospectively examines current workers in lead-using industries (battery manufacture, smelting, etc,), and in non-lead-using control industries in four European countries, with time to pregnancy as the outcome variable. Exposure assessment was mainly by blood lead values, which were available from the late 1970s, supplemented by imputed values where necessary. Three exposure models were studied: short term (recent) exposure, total duration of work in a lead using industry and cumulative exposure. A Cox proportional hazards model was used for the statistical analysis, with covariates for both partners. Results show that among the total of 1104 subjects that took part, 638 were occupationally-exposed to lead at the relevant time. Blood lead levels were mainly less than 50µg/dL. No consistent association of time to pregnancy with lead exposure was found in any of the exposure models. If any impairment of male reproductive function exists at the levels of occupational lead exposure now current, it does not appear to reduce biological fertility.
Descriptors (primary) antifertility effects; lead; male workers
Descriptors (secondary) case-control study; battery and dry cell manufacture; smelting plants; determination in blood; length of exposure
Document type D - Periodical articles
Country / State or ProvinceBelgium; Denmark; Finland; United Kingdom; Italy; Netherlands
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Industries and occupations
Browse category(ies) Antifertility and prenatal effects
Lead and compounds
Inorganic substances
Genetic factors in reaction to exposures