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Document ID (ISN)103420
CIS number 04-264
ISBN(s) 92-4-153017-0
Year 1999
Convention or series no. CICAD No.17
Author(s) Meek M.E.
Inter-Organization Programme for the Sound Management of Chemicals ((IOMC)
Title Butyl benzyl phthalate
Bibliographic information World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1999. iv, 41p. Illus. 181 ref.
Internet access [in English]
Abstract Conclusions of this criteria document: available data in humans are inadequate to serve as a basis for the assessment of the effects of long-term exposure to butyl benzyl phthalate (BBP). The acute toxicity of BBP is relatively low, with oral LD50 values in rats being greater than 2g/kg body weight. Target organs following acute exposure include the haematological and central nervous systems. Available data are inadequate to assess the irritant and sensitizing effects of BBP. On the basis on animal studies, BBP can be considered possibly carcinogenic to humans. In several studies on rats and mice, BBP has induced reduced sperm counts and shown marked developmental effects, but only at dose levels that induce significant toxicity. A tolerable daily intake of 1300µg/kg body weight has been derived for BBP.
Descriptors (primary) IPCS; benzyl butyl phthalate; toxicity evaluation; toxicology
Descriptors (secondary) toxic effects; literature survey; threshold limit values; irritants; ILO; criteria document; WHO; ecotoxicology; animal experiments; lethal dose 50; carcinogenic effects; UNEP
Document type B - Chemical safety information sheets
Country / State or ProvinceCanada; WHO
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Phthalates
Esters and salts