|Document ID (ISN)||103420|
|Convention or series no.
Inter-Organization Programme for the Sound Management of Chemicals ((IOMC)
||Butyl benzyl phthalate
||World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1999. iv, 41p. Illus. 181 ref.
||http://www.who.int/ipcs/publications/cicad/en/cicad17.pdf [in English]
||Conclusions of this criteria document: available data in humans are inadequate to serve as a basis for the assessment of the effects of long-term exposure to butyl benzyl phthalate (BBP). The acute toxicity of BBP is relatively low, with oral LD50 values in rats being greater than 2g/kg body weight. Target organs following acute exposure include the haematological and central nervous systems. Available data are inadequate to assess the irritant and sensitizing effects of BBP. On the basis on animal studies, BBP can be considered possibly carcinogenic to humans. In several studies on rats and mice, BBP has induced reduced sperm counts and shown marked developmental effects, but only at dose levels that induce significant toxicity. A tolerable daily intake of 1300µg/kg body weight has been derived for BBP.
||IPCS; benzyl butyl phthalate; toxicity evaluation; toxicology
||toxic effects; literature survey; threshold limit values; irritants; ILO; criteria document; WHO; ecotoxicology; animal experiments; lethal dose 50; carcinogenic effects; UNEP
||B - Chemical safety information sheets
|Country / State or Province||Canada; WHO|
||Toxic and dangerous substances
|Broad subject area(s)
Esters and salts