|Document ID (ISN)||103419|
|Convention or series no.
||Barker P., Cary R., Dobson S.
Inter-Organization Programme for the Sound Management of Chemicals ((IOMC)
||World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1998. iv, 18p. Illus. 48 ref.
||http://www.who.int/ipcs/publications/cicad/en/cicad11.pdf [in English]
||Conclusions of this criteria document: most available data on the toxicological properties of 1,1,1,2-tetrafluroroethane have been derived from studies conducted with laboratory animals. 1,1,1,2-tetrafluroroethane exhibits relatively low toxicity. There are indications of developmental toxicity following maternal exposure in rats and rabbits. The evidence for carcinogenicity is limited to an increased incidence of Leydig cell adenomas following exposure to 50,000ppm. The substance has not been found to be genotoxic in studies conducted to date.
||IPCS; 1,1,1,2-tetrafluoroethane; toxicology
||toxic effects; literature survey; threshold limit values; ILO; criteria document; WHO; ecotoxicology; animal experiments; carcinogenic effects; UNEP
||B - Chemical safety information sheets
|Country / State or Province||United Kingdom; WHO|
||Toxic and dangerous substances
|Broad subject area(s)