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Document ID (ISN)103419
CIS number 04-263
ISBN(s) 92-4-153011-1
Year 1998
Convention or series no. CICAD No.11
Author(s) Barker P., Cary R., Dobson S.
Inter-Organization Programme for the Sound Management of Chemicals ((IOMC)
Title 1,1,1,2-Tetrafluroroethane
Bibliographic information World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1998. iv, 18p. Illus. 48 ref.
Internet access http://www.who.int/ipcs/publications/cicad/en/cicad11.pdf [in English]
Abstract Conclusions of this criteria document: most available data on the toxicological properties of 1,1,1,2-tetrafluroroethane have been derived from studies conducted with laboratory animals. 1,1,1,2-tetrafluroroethane exhibits relatively low toxicity. There are indications of developmental toxicity following maternal exposure in rats and rabbits. The evidence for carcinogenicity is limited to an increased incidence of Leydig cell adenomas following exposure to 50,000ppm. The substance has not been found to be genotoxic in studies conducted to date.
Descriptors (primary) IPCS; 1,1,1,2-tetrafluoroethane; toxicology
Descriptors (secondary) toxic effects; literature survey; threshold limit values; ILO; criteria document; WHO; ecotoxicology; animal experiments; carcinogenic effects; UNEP
Document type B - Chemical safety information sheets
Country / State or ProvinceUnited Kingdom; WHO
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Halogenated hydrocarbons
Fluorocarbons