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Document ID (ISN)103418
CIS number 04-262
ISBN(s) 92-4-153010-3
Year 1998
Convention or series no. CICAD No.10
Author(s) Wess J., Ahlers H., Dobson S.
Inter-Organization Programme for the Sound Management of Chemicals ((IOMC)
Title 2-Butoxyethanol
Bibliographic information World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1998. iv, 29p. Illus. 109 ref.
Internet access http://www.who.int/ipcs/publications/cicad/en/cicad10.pdf [in English]
Abstract Conclusions of this criteria document: 2-butoxyethanol has moderate acute toxicity and is irritating to the eyes and skin; it is not a skin sensitizer. The principal effect exerted by 2-butoxyethanol and its metabolite 2-butoxyacetic acid is haematotoxicity, with the rat being the most sensitive species. In animals, adverse effects on reproduction and development have not been observed at less than toxic doses. Although there were indications of mutagenicity based on in vitro tests, the results were inconsistent. The absence of structural alerts and the negative findings of in vivo studies are sufficiently reassuring to allow the conclusion that the substance is not mutagenic. Based on the of haemolytic effects observed on pregnant rats exposed during gestation, a tolerable concentration of 13.1mg/m3 has been derived.
Descriptors (primary) IPCS; toxicology; butoxyacetic acid; butoxyethanol
Descriptors (secondary) toxic effects; literature survey; threshold limit values; irritants; ILO; criteria document; WHO; ecotoxicology; animal experiments; in vitro experiments; UNEP
Document type B - Chemical safety information sheets
Country / State or ProvinceUnited Kingdom; USA; WHO
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Glycol ethers