|Document ID (ISN)||103418|
|Convention or series no.
||Wess J., Ahlers H., Dobson S.
Inter-Organization Programme for the Sound Management of Chemicals ((IOMC)
||World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1998. iv, 29p. Illus. 109 ref.
||http://www.who.int/ipcs/publications/cicad/en/cicad10.pdf [in English]
||Conclusions of this criteria document: 2-butoxyethanol has moderate acute toxicity and is irritating to the eyes and skin; it is not a skin sensitizer. The principal effect exerted by 2-butoxyethanol and its metabolite 2-butoxyacetic acid is haematotoxicity, with the rat being the most sensitive species. In animals, adverse effects on reproduction and development have not been observed at less than toxic doses. Although there were indications of mutagenicity based on in vitro tests, the results were inconsistent. The absence of structural alerts and the negative findings of in vivo studies are sufficiently reassuring to allow the conclusion that the substance is not mutagenic. Based on the of haemolytic effects observed on pregnant rats exposed during gestation, a tolerable concentration of 13.1mg/m3 has been derived.
||IPCS; toxicology; butoxyacetic acid; butoxyethanol
||toxic effects; literature survey; threshold limit values; irritants; ILO; criteria document; WHO; ecotoxicology; animal experiments; in vitro experiments; UNEP
||B - Chemical safety information sheets
|Country / State or Province||United Kingdom; USA; WHO|
||Toxic and dangerous substances
|Broad subject area(s)