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CISDOC database

Document ID (ISN)103417
CIS number 04-406
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2004
Convention or series no.
Author(s) Bilban M.
Title Mutagenic testing of workers exposed to toluene-diisocyanates during plastics production process
Bibliographic information May 2004, Vol.45, No.5, p.468-474. 25 ref.
Abstract This study on the potential mutagenicity of toluene diisocyanates (TDI) involved 26 workers exposed to TDI during the production of plastics, together with 21 non-exposed controls. The concentration of TDI ranged between 0.007mg/3 and 0.016mg/3. Structural chromosome aberrations (SCA) were evaluated in 200 lymphocytes of peripheral blood, with an average occurrence of 2.6. Sister chromatid exchanges (SCE) were examined in 50 cells, the average occurrence being 8.127. Micronuclei (MN) were examined in 500 blocked cytokinesis cells, with an average occurrence of 12.07. The corresponding averages of the control group were 1.89 (SCA), 5.52 (SCE) and 4.38 (MN), respectively. The difference between the groups is of statistical significance, thus confirming the mutagenic activity of toluene diisocyanates or their metabolites.
Descriptors (primary) mutagenic effects; plastics industry; tolylene diisocyanate
Descriptors (secondary) case-control study; mutagenicity tests; determination in air; cytological effects; chromosome changes
Document type D - Periodical articles
Country / State or ProvinceSlovenia
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures
Isocyanates
Plastics industry
Cyano compounds
Chemical industry