|Document ID (ISN)||103370|
|ISSN - Serial title
||1232-1966 - AAEM - Annals of Agricultural and Environmental Medicine
|Convention or series no.
||Lange J.H., Mastrangelo G., Fedeli U., Fadda E., Rylander R., Lee E.
||Endotoxin exposure and lung cancer mortality by type of farming: Is there a hidden dose-response relationship?
||2003, Vol.10, No.2, p.229-232. 32 ref.
||http://www.aaem.pl/pdf/10229.pdf [in English]
||Previous studies have suggested that persons in occupations exposed to endotoxins have a reduced rate of lung and respiratory system cancer. In particular, an earlier investigation found a significantly reduced risk of all sites malignant neoplasms in white male crop and livestock farmers, and black male and female crop farmers. The present study provides data on lung and respiratory system cancers in the same workers. Data were obtained from occupation and industry-coded death certificates collected from 26 US states for the period 1984-1993. Cause, sex and race specific proportionate mortality ratios (PMRs) were calculated using a NIOSH computer program. In each sex and race group, respiratory and lung cancer PMRs were lower than unity. Pooled lung cancer PMR was 0.80 in crop farmers and 0.70 in livestock farmers. These findings, together with those of an earlier study on Californian farmers, suggest a decreasing lung cancer risk with increasing endotoxin exposure, with a possible inverse dose-response relationship.
||bacterial toxins; mortality; dose-response relationship; agriculture; lung cancer
||race-linked differences; livestock rearing; public OSH institutions; frequency rates; crop farming; sex-linked differences; computer programme; USA
||D - Periodical articles
|Country / State or Province||Italy; Korea, Republic of; Sweden; USA|
||Agriculture, fishing, animal husbandry
|Broad subject area(s)
Diseases of the respiratory system (except for pneumoconiosis & similar)