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Document ID (ISN)103370
CIS number 04-464
ISSN - Serial title 1232-1966 - AAEM - Annals of Agricultural and Environmental Medicine
Year 2003
Convention or series no.
Author(s) Lange J.H., Mastrangelo G., Fedeli U., Fadda E., Rylander R., Lee E.
Title Endotoxin exposure and lung cancer mortality by type of farming: Is there a hidden dose-response relationship?
Bibliographic information 2003, Vol.10, No.2, p.229-232. 32 ref.
Internet access [in English]
Abstract Previous studies have suggested that persons in occupations exposed to endotoxins have a reduced rate of lung and respiratory system cancer. In particular, an earlier investigation found a significantly reduced risk of all sites malignant neoplasms in white male crop and livestock farmers, and black male and female crop farmers. The present study provides data on lung and respiratory system cancers in the same workers. Data were obtained from occupation and industry-coded death certificates collected from 26 US states for the period 1984-1993. Cause, sex and race specific proportionate mortality ratios (PMRs) were calculated using a NIOSH computer program. In each sex and race group, respiratory and lung cancer PMRs were lower than unity. Pooled lung cancer PMR was 0.80 in crop farmers and 0.70 in livestock farmers. These findings, together with those of an earlier study on Californian farmers, suggest a decreasing lung cancer risk with increasing endotoxin exposure, with a possible inverse dose-response relationship.
Descriptors (primary) bacterial toxins; mortality; dose-response relationship; agriculture; lung cancer
Descriptors (secondary) race-linked differences; livestock rearing; public OSH institutions; frequency rates; crop farming; sex-linked differences; computer programme; USA
Document type D - Periodical articles
Country / State or ProvinceItaly; Korea, Republic of; Sweden; USA
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s) Biological hazards
Browse category(ies) Agriculture
Diseases of the respiratory system (except for pneumoconiosis & similar)