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Document ID (ISN)103360
CIS number 04-470
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2004
Convention or series no.
Author(s) Biagini R.E., Sammons D.L., Smith J.P., Page E.H., Snawder J.E., Striley C.A.F., MacKenzie B.A.
Title Determination of serum IgG antibodies to Bacillus anthracis protective antigen in environmental sampling workers using a fluorescent covalent microsphere immunoassay
Bibliographic information Aug. 2004, Vol.61, No.8, p.703-708. Illus. 28 ref.
Abstract To evaluate potential exposure to Bacillis anthracis (Ba) spores in 28 sampling and decontamination workers in the aftermath of an anthrax terror attack in October 2001, serum Ba anti-protective antigen (PA) specific IgG antibodies were determined using a newly developed fluorescent covalent microsphere immunoassay (FCMIA). Four serum samples gave positive anti-PA IgG results, from the pre-entry and follow up samples of two workers who had received their last dose of anthrax vaccine in 2000. It appears that the workers either had insufficient exposure to Ba spores to cause the production of anti-PA IgG antibodies or they were exposed to anthrax spores without producing antibody. The FCMIA appears to be a fast, sensitive, accurate and precise method for the measurement of anti-PA IgG antibodies.
Descriptors (primary) anthrax; terrorism; exposure tests; biological hazards
Descriptors (secondary) spores; immunoglobulins; antigens; determination in blood; exposure evaluation; sampling and analysis; vaccination; antibodies
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Commerce, services, offices
Broad subject area(s) Biological hazards
Browse category(ies) Bacterial and parasitic diseases
Biological hazards
Violence and terrorism
Biological monitoring