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Document ID (ISN)103359
CIS number 04-328
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2004
Convention or series no.
Author(s) Acquavella J.F., Delzell E., Cheng H., Lynch C.F., Johnson G.
Title Mortality and cancer incidence among alachlor manufacturing workers 1968-99
Bibliographic information Aug. 2004, Vol.61, No.8, p.680-685. 20 ref.
Abstract Alachlor is the active ingredient in herbicide formulations used widely on corn, soybeans and other crops. It has been found to cause nasal, stomach, and thyroid tumours in rodent studies, however at levels that are much higher than likely human exposures. This study was carried out to evaluate mortality rates from 1968 to 1999 and cancer incidence rates from 1969 to 1999 among workers at an alachlor manufacturing plant. Worker mortality and cancer incidence rates were compared to corresponding rates for the Iowa state general population. Analyses addressed potential intensity and duration of exposure. There were no cancers of the types found in toxicology studies and no discernible relation between cancer incidence for any site and years of alachlor exposure or time since first exposure. These findings are significant considering that these workers had chronic exposure during extended manufacturing campaigns, while use in agriculture is typically limited to a few days or weeks each year.
Descriptors (primary) herbicides; chemical industry; Iowa; risk factors; mortality; cancer; Lasso
Descriptors (secondary) carcinogens; USA; toxicology; frequency rates; animal experiments; long-term exposure; cohort study
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Industries and occupations
Occupational medicine, epidemiology
Browse category(ies) Agricultural chemicals
Chemical industry