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Document ID (ISN)103341
CIS number 04-326
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2004
Convention or series no.
Author(s) Attfield M.D., Costello J.
Title Quantitative exposure-response relationship for silica dust and lung cancer in Vermont granite workers
Bibliographic information Feb. 2004, Vol.45, No.2, p.129-138. Illus. 27 ref.
Abstract Exposure evaluation data for the years 1924 to 1977 were analysed in conjunction with mortality data to examine quantitative exposure-response for silica, lung cancer and other lung diseases in a cohort of granite workers in the U.S. state of Vermont. The findings indicated a clear relationship of lung cancer, tuberculosis, pneumoconiosis, non-malignant lung disease and kidney cancer with cumulative exposure. An exposure to silica of 0.05mg/m3 from age 20 to 64 was associated with a lifetime excess risk of lung cancer for white males of 27/1000. The results of this study of workers exposed almost exclusively to silica and no other major occupational confounding exposures indicate a clear exposure-response for lung cancer.
Descriptors (primary) Vermont; occupational diseases; granite; quarrying industry; lung cancer; respirable dust; silica
Descriptors (secondary) USA; tuberculosis; renal cancer; lung diseases; statistical evaluation; hazard evaluation; cohort study; dose-response relationship; pneumoconiosis
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Mines and quarries
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Mining and quarrying
Bacterial and parasitic diseases