| Document ID (ISN) | 103165 |
| CIS number |
04-165 |
| ISBN(s) |
3-89701-932-9 |
| Year |
2003 |
| Convention or series no. |
Fb 975
|
| Author(s) |
Fahrig R., Görlitz B.D., Preiß A.
Bundesanstalt für Arbeitsschutz und Arbeitsmedizin |
| Title |
Genotoxic effects of 3,3'-dihydroxybenzidine including stability investigations |
| Original title |
Prüfung der genotoxischen Wirkung von 3,3'-Dihydroxybenzidin einschließlich Untersuchungen zur Stabilität [in German] |
| Bibliographic information |
Wirtschaftsverlag NW, Postfach 10 11 10, 27511 Bremerhaven, Germany, 2003. 196p. Illus. 7 ref. Price: EUR 17.00. |
| Abstract |
In this study, the mutagenic activity of 3,3'-dihydroxybenzidine in various biological systems was examined. 3,3'-dihydroxybenzidine induced isolated mutations in bacteria as well as genetic mutations and chromosomal aberrations in cell cultures (V79). In a UDS test (non-programmed DNA synthesis) on rat hepatocytes, toxic effects were observed on the hepatocytes, but there was no increase in DNA synthesis. There was no evidence of 3,3'-dihydroxybenzidine toxicity in a micronucleus test on mice. The stability of 3,3'-dihydroxybenzidine in acetonitrile and in aqueous and organic solvent mixtures was also examined. In the latter case, degradation was observed in both buffered and unbuffered mixtures. |
| Descriptors (primary) |
mutagenic effects; stability; 3,3'-dihydroxybenzidine |
| Descriptors (secondary) |
toxic effects; chromosome changes; in vitro experiments; animal experiments |
| Document type |
E - Books, reports, proceedings |
| Country / State or Province | Germany |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Aromatic amines
Genetic factors in reaction to exposures
Antifertility and prenatal effects
|
