ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)103120
CIS number 04-26
Year 2004
Convention or series no. ECETOC JACC No.44
Title 1,1,1,3,3-Pentafluoropropane (HFC-245fa) (CAS No. 460-73-1)
Bibliographic information European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), Avenue E. Van Nieuwenhuyse 4, Bte. 6, 1160 Bruxelles, Belgium, June 2004. 44p. Illus. 51 ref.
Abstract Conclusions of this criteria document: animal experiments show that 1,1,1,3,3-pentafluoropropane (HFC-245fa) presents a low level of acute inhalation toxicity; long-term exposures at concentrations of 50,000ppm were tolerated with minimal signs of toxicity; at that level, HFC-245fa demonstrated no developmental effects. In genetic testing, HFC-245fa was not mutagenic in bacteria, although it induced some chromosome aberrations in cultured human lymphocytes; no micronuclei were found in mice exposed to 100,000ppm. These data suggest that HFC-245fa does not represent a significant carcinogenic hazard. To date, no adverse effects have been reported in humans.
Descriptors (primary) 1,1,1,3,3-pentafluoropropane; toxicology; fluoropropanes; fluorinated hydrocarbons
Descriptors (secondary) lymphocytes; animal experiments; criteria document; chromosome changes; in vitro experiments
Document type B - Chemical safety information sheets
Country / State or ProvinceBelgium
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Fluorocarbons
Genetic factors in reaction to exposures
Halogenated hydrocarbons