|Document ID (ISN)||103009|
|Convention or series no.
||People and Work Research Reports 63
||Inherited DNA repair capacity and individual responses to carcinogens
||Finnish Institute of Occupational Health, FIOH-Bookstore, Topeliuksenkatu 41 a A, 00250 Helsinki, Finland, 2004. 83p. Illus. Bibl.ref. Price: EUR 18.00.
||http://ethesis.helsinki.fi/julkaisut/bio/bioja/vk/tuimala/inherite.pdf [in English]
||Although humans are exposed daily to genotoxic carcinogens, the body has efficient means to deal with absorbed harmful compounds. However, wide inter-individual differences have been shown to exist concerning the capacity to respond to chemical carcinogens. The aim of this thesis was to study the influence of polymorphisms in various DNA repair genes, the cytogenic damage (mutagen sensitivity, chromosomal aberrations and sister chromatide exchange) and the risk of cancer in the upper aerodigestive tract. The results show that polymorphism of DNA repair genes are able to influence the individual responses to genotoxic and carcinogenic exposures.
||mutagenic effects; carcinogens; individual susceptibility; hereditary variables; DNA
||enzymes; cancer; chromosome changes; genetic effects; thesis
||E - Books, reports, proceedings
|Country / State or Province||Finland|
|Broad subject area(s)
||Genetic factors in reaction to exposures
Antifertility and prenatal effects