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Document ID (ISN)103009
CIS number 04-167
ISBN(s) 951-802-574-6
Year 2004
Convention or series no. People and Work Research Reports 63
Author(s) Tuimala J.
Title Inherited DNA repair capacity and individual responses to carcinogens
Bibliographic information Finnish Institute of Occupational Health, FIOH-Bookstore, Topeliuksenkatu 41 a A, 00250 Helsinki, Finland, 2004. 83p. Illus. Bibl.ref. Price: EUR 18.00.
Internet access http://ethesis.helsinki.fi/julkaisut/bio/bioja/vk/tuimala/inherite.pdf [in English]
Abstract Although humans are exposed daily to genotoxic carcinogens, the body has efficient means to deal with absorbed harmful compounds. However, wide inter-individual differences have been shown to exist concerning the capacity to respond to chemical carcinogens. The aim of this thesis was to study the influence of polymorphisms in various DNA repair genes, the cytogenic damage (mutagen sensitivity, chromosomal aberrations and sister chromatide exchange) and the risk of cancer in the upper aerodigestive tract. The results show that polymorphism of DNA repair genes are able to influence the individual responses to genotoxic and carcinogenic exposures.
Descriptors (primary) mutagenic effects; carcinogens; individual susceptibility; hereditary variables; DNA
Descriptors (secondary) enzymes; cancer; chromosome changes; genetic effects; thesis
Document type E - Books, reports, proceedings
Country / State or ProvinceFinland
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Genetic factors in reaction to exposures
Antifertility and prenatal effects