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CISDOC database

Document ID (ISN)102932
CIS number 03-1623
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 2002
Convention or series no.
Author(s) Cedergren M.I., Selbing A.J., KńllÚn B.A.J.
Title Risk factors for cardiovascular malformation - A study based on prospectively collected data
Bibliographic information Feb. 2002, Vol.28, No.1, p.12-17. 23 ref.
Abstract This study included 277 women who had infants with a severe cardiac defect. Data on parental age, maternal reproductive history, disease in early pregnancy, reported maternal use of drugs and alcohol, smoking habits, parental occupation and maternal body mass index (BMI) were extracted from medical records. Maternal diabetes mellitus was associated with an increased risk for cardiovascular malformation (odds ratio (OR) 2.38), as was a high BMI (> 29, OR 1.46). A tendency towards an increased risk was found for involuntary childlessness, spontaneous abortion, thyroid drugs and nonsteroid anti-inflammatory drugs. Some known risk factors for cardiac defects (eg. maternal diabetes mellitus and the use of antiepileptics) could be identified in this study but other postulated risk factors could not be verified. It is possible, however, that there is an association with the use of nonsteroid anti-inflammatory drugs or drugs for thyroid disease. The relationship between a high BMI and cardiovascular malformation observed in this study may be explained by impaired maternal glucose tolerance.
Descriptors (primary) children; complications of pregnancy; risk factors; teratogenic effects; heart diseases
Descriptors (secondary) non-occupational factors; diabetes mellitus; drugs; alcoholism; body weight; age; abortion; case-control study; smoking
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Cardiovascular diseases
Diseases of the reproductive system
Genetic factors in reaction to exposures
Alcohol and drug abuse
Antifertility and prenatal effects