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Document ID (ISN)102929
CIS number 03-1774
ISSN - Serial title 1219-1221 - Central European Journal of Occupational and Environmental Medicine
Year 2002
Convention or series no.
Author(s) Ghiassi-Nejad M., Varzegar R., Zakeri F., Rasouli-Nejad S.
Title Analysis of chromosomal aberrations, micronuclei and sister chromatid exchanges in lymphocytes of workers of a phosphate fertilizer factory
Bibliographic information 2002, Vol.8, No.4, p.277-282. Illus. 17 ref.
Abstract The frequencies of chromosomal aberrations, micronuclei and sister chromatid exchanges in peripheral blood lymphocytes were studied in 15 workers of an Iranian phosphate fertilizer factory exposed to chemicals and radioactive substances and in 15 unexposed controls. The exposed individuals showed higher frequencies of dicentrics as well as acentrics than the normal controls. The mean frequencies of chromosomal aberrations per 100 metaphases of workers and non-exposed controls were 5.06 and 1.52, respectively; those of micronucleated cells per 1000 binucleated lymphocytes of workers and controls were 47▒8 and 12▒5, respectively and the mean number of sister chromatid exchanges per 100 cells in workers and controls were 4.6▒2.8 and 2.80▒0.37, respectively. These results confirm the existence of clastogenic and genotoxic effects of chemical agents and radioactive materials.
Descriptors (primary) radioactive substances; chemical products; fertilizer industry; chromosome changes; risk factors; genetic effects
Descriptors (secondary) genetic abnormalities; case-control study; DNA; Iran, Islamic Republic of
Document type D - Periodical articles
Country / State or ProvinceIran, Islamic Republic of
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Chemical industry
Genetic factors in reaction to exposures