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Document ID (ISN)102730
CIS number 03-1754
ISSN - Serial title 0465-546X - Medicina y seguridad del trabajo
Year 2001
Convention or series no.
Author(s) Letourneux M.
Title Evaluation of the risk of occurrence of benign asbestos-related diseases (dose-response relationship, time-response relationship and co-factors)
Original title Evaluación del riesgo de que se produzcan patologías asbestósicas benignas (relación dosis-efecto, relación tiempo-efecto y cofactores) [in Spanish]
Bibliographic information 2001, Vol.XLVIII, No.191, p.87-96. 70 ref.
Abstract Despite the lack of precision of asbestos exposure assessments and the limitations of the main diagnostic tool (standard X ray films), several issues concerning the risk of development of asbestos-related diseases are well established. For asbestosis, now a rare disease, the existence of a positive dose-response relationship, with a threshold or no-effect level, has been clearly demonstrated. The slope of the relationship curve is steeper for amphiboles than for chrysotile, as it is for increased fibre length. Asbestosis is associated with an increased risk of bronchial carcinoma; however it is now known that exposure to asbestos increases the risk of cancer even in the absence of any radiographic signs of pulmonary fibrosis. Pleural plaques occur even when the level of asbestos exposure is low. They are not only dose-dependant but are also latency-related. They have no prognostic significance in asbestos-exposed workers, but are associated with an increased risk for the subsequent development of mesothelioma and bronchial carcinoma when compared to the risk of the general population. Diffuse pleural thickening is associated with higher levels of asbestos exposure than those associated with pleural plaques.
Descriptors (primary) asbestos; latency; dose-response relationship; hazard evaluation; asbestosis
Descriptors (secondary) amphibole; bronchial cancer; pleural mesothelioma; pleural diseases; pulmonary fibrosis
Document type D - Periodical articles
Country / State or ProvinceFrance
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Pneumoconioses
Asbestos
Risk evaluation