|Document ID (ISN)||102703|
|Convention or series no.
||ECETOC JACC No.42
||Tetrafluoroethylene (CAS No.116-14-3)
||European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), Avenue E. Van Nieuwenhuyse 4, Bte. 6, 1160 Bruxelles, Belgium, Dec. 2003. 75p. Illus. 141 ref.
||Conclusions of this criteria document: in laboratory animals, the primary effect of tetrafluoroethylene (TFE) is damage to the kidney. Long-term exposures result in a low level of toxicity manifesting as kidney effects and anaemia in rats and mice, and possibly testicular changes in hamsters. No specific study of the reproductive effects of TFE is available. TFE is not genotoxic either in vitro or in vivo. The main metabolite (cysteine conjugate) of TFE, S 1,1,2,2- tetrafluoroethyl-L-cysteine, is also not mutagenic in vivo. In long-term carcinogenicity studies in rats and mice, repeated inhalation of high doses of TFE produced tumours of the kidney in rats and mice and in the liver of mice. In mice, a higher number of tumours of the haematopoietic system were also observed. The current lack of knowledge about the mechanisms involved in the development of these three tumours types precludes a full evaluation of the hazard to humans from exposure to TFE .
||animal experiments; criteria document; in vitro experiments
||B - Chemical safety information sheets
|Country / State or Province||Belgium|
||Toxic and dangerous substances
|Broad subject area(s)