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Document ID (ISN)102585
CIS number 03-1753
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2003
Convention or series no.
Author(s) Calvert G.M., Rice F.L., Boiano J.M., Sheehy J.W., Sanderson W.T.
Title Occupational silica exposure and risk of various diseases: An analysis using death certificates from 27 states of the United States
Bibliographic information Feb. 2003, Vol.60, No.2, p.122-129. 88 ref.
Abstract This matched case-control study was carried out to investigate the relationship between exposure to silica and a number of diseases generally associated with exposure to silica. Data were collected from the United States National Occupational Mortality Surveillance system. Cases were subjects whose death certificate mentioned the disease of interest. Control groups consisted of subjects whose death certificate did not mention any of several diseases reported to be associated with crystalline silica exposure. Subjects were assigned into a qualitative crystalline silica exposure category based on the occupation mentioned on their death certificate. Cases with detectable crystalline silica exposure had a significantly increased risk for silicosis, chronic obstructive pulmonary disease (COPD), pulmonary tuberculosis and rheumatoid arthritis. A significant trend of increasing risk with increasing silica exposure was observed for these same conditions and for lung cancer. Those with the highest exposure to crystalline silica had a significantly increased risk for silicosis, lung cancer, COPD and pulmonary tuberculosis. Finally, those with silicosis had a significantly increased risk for COPD, pulmonary tuberculosis and rheumatoid arthritis.
Descriptors (primary) USA; hazard evaluation; silica; occupational diseases
Descriptors (secondary) obstructive ventilatory impairment; rheumatoid arthritis; tuberculosis; chronic diseases; frequency rates; lung cancer; silicosis; case-control study; dose-response relationship; mortality
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Risk evaluation
Bacterial and parasitic diseases