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Document ID (ISN)102503
CIS number 03-1768
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2003
Convention or series no.
Author(s) Başaran N., Shubair M., ▄ndeğer ▄., Kars A.
Title Monitoring DNA damage in foundry and pottery workers exposed to silica by the alkaline comet assay
Bibliographic information June 2003, Vol.43, No.6, p.602-610. 43 ref.
Abstract Workers in the foundry and pottery industries are exposed to a mixture of chemicals including silica, a substance widely suspected of causing genetic alterations. To investigate the potential hazard associated with the occupational exposure to silica, DNA damages in the peripheral lymphocytes of 30 foundry and 22 pottery workers were examined using the alkaline gel electrophoresis or comet assay method, and compared with 52 healthy subjects with no history of occupational exposure to silica or other chemicals. The DNA damage observed in the lymphocytes of both foundry and pottery workers was significantly higher than that among controls. DNA damage was also caused by cigarette smoking, since the damage observed in smoking silica-exposed workers compared with the non-smoking workers was significantly higher.
Descriptors (primary) DNA; silica; foundries; pottery industry; risk factors
Descriptors (secondary) lymphocytes; Turkey; smoking; immunoelectrophoresis; experimental pathology; genetic effects; case-control study
Document type D - Periodical articles
Country / State or ProvinceTurkey
Subject(s) Mines and quarries
Broad subject area(s) Chemical safety
Browse category(ies) Genetic factors in reaction to exposures
Glass, pottery and related materials
Foundries, metalcasting and forging operations