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Document ID (ISN)102409
CIS number 03-1190
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 2001
Convention or series no.
Author(s) Nersesyan A.K., Boffetta P., Sarkisyan T.F, Zalinyan G.G., Arutyunyan R.M.
Title Chromosome aberrations in lymphocytes of persons exposed to an earthquake in Armenia
Bibliographic information Apr. 2001, Vol.27, No.2, p.120-124. 22 ref.
Abstract Chromosome aberrations were measured in blood samples taken from 41 victims of the earthquake that hit Armenia in 1988 and in samples of 47 reference blood donors. The victims suffered from severe psychoemotional stress but were otherwise healthy. All the samples were taken 2 to 3 weeks after the earthquake. All the subjects were lifetime nonsmokers. The subjects exposed to the earthquake had a higher proportion of cells with chromosome aberrations (3.1) than the referents (1.7). The difference persisted when the values were adjusted for age and sex (relative risk (RR) 1.9). The exposed subjects also had a lower percentage of cells with 46 chromosomes than the referents. This study suggests an increase in chromosome aberrations in the lymphocytes of victims of a severe earthquake. If not due to bias or confounding, the difference may reflect the effect of either environmental exposures related to the earthquake or severe psychogenic stress. The levels of chromosome aberrations found among the earthquake victims in this study are comparable with those found in prospective studies of long-term cancer risk.
Descriptors (primary) lymphocytes; chromosome changes; earthquakes; Armenia
Descriptors (secondary) mass psychogenic illness; neuropsychic stress; analysis of chromosome aberrations; case-control study; cancer
Document type D - Periodical articles
Country / State or ProvinceArmenia; France
Subject(s) Psychology and sociology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Antifertility and prenatal effects
Natural phenomena
Genetic factors in reaction to exposures