|Document ID (ISN)||102276|
|Convention or series no.
||Liteplo R.G., Meek M.E., Lewis M.
Inter-Organization Programme for the Sound Management of Chemicals (IOMC)
||World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 2003. iv, 57p. Illus. 255 ref.
||http://www.who.int/ipcs/publications/cicad/en/cicad54.pdf [in English]
||Conclusions of this criteria document: ethylene oxide is an ocular, respiratory and dermal irritant and a sensitizing agent; neurological effects (sensorimotor polyneuropathy) have been observed in workers exposed to relatively high concentrations. Based on animal studies, cancer is considered the critical end- point for effects of ethylene oxide on humans. There is some evidence of an association between exposure to ethylene oxide and haematological cancers, and of clastogenic changes induced in exposed workers. In experiment animals, ethylene oxide is foetotoxic and induces germ cell mutations and clastogenic changes.
||IPCS; ethylene oxide; toxicology
||toxic effects; sensitization; irritants; ILO; UNEP; WHO; cancer; ecotoxicology; animal experiments; lethal concentration 50; genetic effects; haematological effects; neurological effects; criteria document; literature survey
||B - Chemical safety information sheets
|Country / State or Province||Canada; WHO|
||Toxic and dangerous substances
|Broad subject area(s)
||Genetic factors in reaction to exposures