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Document ID (ISN)102276
CIS number 03-1088
ISBN(s) 92-4-153054-5
Year 2003
Convention or series no. CICAD No.54
Author(s) Liteplo R.G., Meek M.E., Lewis M.
Inter-Organization Programme for the Sound Management of Chemicals (IOMC)
Title Ethylene oxide
Bibliographic information World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 2003. iv, 57p. Illus. 255 ref.
Internet access http://www.who.int/ipcs/publications/cicad/en/cicad54.pdf [in English]
Abstract Conclusions of this criteria document: ethylene oxide is an ocular, respiratory and dermal irritant and a sensitizing agent; neurological effects (sensorimotor polyneuropathy) have been observed in workers exposed to relatively high concentrations. Based on animal studies, cancer is considered the critical end- point for effects of ethylene oxide on humans. There is some evidence of an association between exposure to ethylene oxide and haematological cancers, and of clastogenic changes induced in exposed workers. In experiment animals, ethylene oxide is foetotoxic and induces germ cell mutations and clastogenic changes.
Descriptors (primary) IPCS; ethylene oxide; toxicology
Descriptors (secondary) toxic effects; sensitization; irritants; ILO; UNEP; WHO; cancer; ecotoxicology; animal experiments; lethal concentration 50; genetic effects; haematological effects; neurological effects; criteria document; literature survey
Document type B - Chemical safety information sheets
Country / State or ProvinceCanada; WHO
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Genetic factors in reaction to exposures
Ethers
Ethylene oxide