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Document ID (ISN)102122
CIS number 03-1316
ISBN(s) 0-7176-2700-4
Year 2003
Convention or series no. HSE Research Report RR 122
Author(s) Jones M., Cullinan P., Durham S., Newman Taylor A.
Health and Safety Executive
Title Cellular aspects of occupational asthma: Immunological studies in isocyanate exposed subjects
Bibliographic information HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 2WA, United Kingdom, 2003. ix, 84p. Illus. 44 ref. Price: GBP 15.00.
Internet access http://www.hse.gov.uk/research/rrpdf/rr122.pdf [in English]
Abstract The cellular and molecular mechanisms that induce asthma due to expsoure to low molecular weight chemicals are not fully understood. The aim of this project was to gain a better understanding of the mechanisms of low molecular weight chemical haptens and in particular isocyanates. The study was carried out among occupational asthma patients in a university hospital, and involved bronchoscopy, specific IgE and T-cell studies. It was found that there was a lack of local IgE and IL-4 production in the lungs following challenge in patients allergic to isocyanates, which parallels the lack of detectable specific IgE in the serum of the majority of patients with isocyanate-induced asthma. There was, however, evidence of local tissue eosinophilia and IL-5 production. These findings suggest that isocyanate induced asthma in humans is a Th2 type response in which IgE does not have an obligatory role.
Descriptors (primary) allergens; immunoglobulins; immunology; isocyanates; allergic asthma; occupational diseases
Descriptors (secondary) United Kingdom; report; interleukins; eosinophilia; bronchoscopy; allergy tests; inhalation tests; determination in blood; hospitals
Document type E - Books, reports, proceedings
Country / State or ProvinceUnited Kingdom
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
Cyano compounds
Allergies