| Document ID (ISN) | 102122 |
| CIS number |
03-1316 |
| ISBN(s) |
0-7176-2700-4 |
| Year |
2003 |
| Convention or series no. |
HSE Research Report RR 122
|
| Author(s) |
Jones M., Cullinan P., Durham S., Newman Taylor A.
Health and Safety Executive |
| Title |
Cellular aspects of occupational asthma: Immunological studies in isocyanate exposed subjects |
| Bibliographic information |
HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 2WA, United Kingdom, 2003. ix, 84p. Illus. 44 ref. Price: GBP 15.00. |
| Internet access |
http://www.hse.gov.uk/research/rrpdf/rr122.pdf [in English]
|
| Abstract |
The cellular and molecular mechanisms that induce asthma due to expsoure to low molecular weight chemicals are not fully understood. The aim of this project was to gain a better understanding of the mechanisms of low molecular weight chemical haptens and in particular isocyanates. The study was carried out among occupational asthma patients in a university hospital, and involved bronchoscopy, specific IgE and T-cell studies. It was found that there was a lack of local IgE and IL-4 production in the lungs following challenge in patients allergic to isocyanates, which parallels the lack of detectable specific IgE in the serum of the majority of patients with isocyanate-induced asthma. There was, however, evidence of local tissue eosinophilia and IL-5 production. These findings suggest that isocyanate induced asthma in humans is a Th2 type response in which IgE does not have an obligatory role. |
| Descriptors (primary) |
allergens; immunoglobulins; immunology; isocyanates; allergic asthma; occupational diseases |
| Descriptors (secondary) |
United Kingdom; report; interleukins; eosinophilia; bronchoscopy; allergy tests; inhalation tests; determination in blood; hospitals |
| Document type |
E - Books, reports, proceedings |
| Country / State or Province | United Kingdom |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
Cyano compounds
Allergies
|
