|Document ID (ISN)||102122|
|Convention or series no.
||HSE Research Report RR 122
||Jones M., Cullinan P., Durham S., Newman Taylor A.
Health and Safety Executive
||Cellular aspects of occupational asthma: Immunological studies in isocyanate exposed subjects
||HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 2WA, United Kingdom, 2003. ix, 84p. Illus. 44 ref. Price: GBP 15.00.
||http://www.hse.gov.uk/research/rrpdf/rr122.pdf [in English]
||The cellular and molecular mechanisms that induce asthma due to expsoure to low molecular weight chemicals are not fully understood. The aim of this project was to gain a better understanding of the mechanisms of low molecular weight chemical haptens and in particular isocyanates. The study was carried out among occupational asthma patients in a university hospital, and involved bronchoscopy, specific IgE and T-cell studies. It was found that there was a lack of local IgE and IL-4 production in the lungs following challenge in patients allergic to isocyanates, which parallels the lack of detectable specific IgE in the serum of the majority of patients with isocyanate-induced asthma. There was, however, evidence of local tissue eosinophilia and IL-5 production. These findings suggest that isocyanate induced asthma in humans is a Th2 type response in which IgE does not have an obligatory role.
||allergens; immunoglobulins; immunology; isocyanates; allergic asthma; occupational diseases
||United Kingdom; report; interleukins; eosinophilia; bronchoscopy; allergy tests; inhalation tests; determination in blood; hospitals
||E - Books, reports, proceedings
|Country / State or Province||United Kingdom|
|Broad subject area(s)
||Diseases of the respiratory system (except for pneumoconiosis & similar)