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Document ID (ISN)102039
CIS number 03-1305
ISSN - Serial title 1232-1087 - International Journal of Occupational Medicine and Environmental Health
Year 2003
Convention or series no.
Author(s) Pałczyński C., Walusiak J., Krakowiak A., Szymczak W., Wittczak T., Ruta U., Gˇrski P.
Title Nasal lavage fluid examination in diagnostics of occupational allergy to chloramine
Bibliographic information 2003, Vol.16, No.3, p.231-240. Illus. 26 ref.
Abstract Chloramine T is a known sensitizing agent in the occupational environment of health care workers. The aim of this study was to evaluate the usefulness of the nasal challenge test in diagnostics of respiratory allergy to chloramine T. The study was conducted in six subjects with chloramine T asthma and rhinitis. Two control groups comprised seven atopic subjects with asthma and rhinitis and six healthy persons. All controls had negative results of prick tests with chloramine T and none displayed any respiratory symptoms under exposure to the agent. A "nasal pool" technique was used to evaluate morphological and biochemical parameters in nasal washings before and 30min, 4h and 24h after the provocation with chloramine T and placebo. A significant increase was found in the total count and percentage of eosinophils and basophils, albumin, tryptase and eosinophil cationic proteins in the nasal lavage fluid from patients with chloramine T respiratory allergy when compared to both control groups. The results indicate the applicability of the "nasal pool" technique as a diagnostic procedure in chloramine T-induced airway allergy.
Descriptors (primary) chloramine-T; diagnosis; allergic respiratory disorders; health care personnel; disinfectants
Descriptors (secondary) allergens; rhinitis; asthma; description of technique; skin tests; individual susceptibility; determination in biological matter; case-control study
Document type D - Periodical articles
Country / State or ProvincePoland
Subject(s) Commerce, services, offices
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Health care services