| Document ID (ISN) | 101981 |
| CIS number |
03-745 |
| ISSN - Serial title |
0003-4878 - Annals of Occupational Hygiene |
| Year |
2001 |
| Convention or series no. |
|
| Author(s) |
Jongeneelen F.J. |
| Title |
Benchmark guideline for urinary 1-hydroxypyrene as biomarker of occupational exposure to polycyclic aromatic hydrocarbons |
| Bibliographic information |
Jan. 2001, Vol.45, No.1, p.3-13. 70 ref. |
| Abstract |
Urinary 1-hydroxypyrene has been proposed as an indicator of exposure to polycyclic aromatic hydrocarbons (PAH). This article discusses a proposed three-level guideline for exposure evaluation. The first level is the 95th percentile in non-occupational exposed controls, namely 0.24µmol/mol and 0.76µmol/mol creatinine for non-smokers and smokers, respectively. Next, 1.4µmol/mol creatinine is the lowest reported level at which no genotoxic effects were found among exposed workers and is therefore proposed as the second level of the guideline. In two types of industry, coke ovens and primary aluminium production, airborne PAH concentrations and urinary 1-hydroxypyrene concentrations in exposed workers have been studied. The concentration of 1-hydroxypyrene in urine equal to the occupational exposure limit is 2.3µmol/mol creatinine and 4.9µmol/mol creatinine, respectively, in these two industries. These latter values present the third level of the guideline. |
| Descriptors (primary) |
aromatic hydrocarbons; urinary excretion; biological threshold limits; urinary metabolites; polycyclic hydrocarbons |
| Descriptors (secondary) |
aluminium industry; pyrene; creatinine; directive; exposure evaluation; 1-hydroxypyrene; exposure tests; coke ovens |
| Document type |
D - Periodical articles |
| Country / State or Province | Netherlands |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Aromatic hydrocarbons
Occupational exposure limits
Polycyclic hydrocarbons
|
