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Document ID (ISN)101953
CIS number 03-670
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 2001
Convention or series no.
Author(s) Eisen E.A., Bardin J., Gore R., Woskie S.R., Hallock M.F., Monson R.R.
Title Exposure-response models based on extended follow-up of a cohort mortality study in the automobile industry
Bibliographic information Aug. 2001, Vol.27, No.4, p.240-249. Illus. 29 ref.
Abstract This report describes the extended follow-up of a cohort of 46,399 automobile manufacturing workers with potential exposure to metalworking fluids (MWF). The outcomes of cancers of the oesophagus, stomach, colon, rectum, liver, pancreas, larynx, skin, prostate and brain, as well as leukaemia, were recorded. Standardized mortality ratios were computed for the most recent ten years of follow-up, as well as for the entire study period. Adjusted relative risks were estimated in Poisson regression models. Associations were found between: straight MWF exposure and oesophageal, laryngeal and rectal cancer; soluble MWF exposure and cancer of the oesophagus, larynx, skin and brain; synthetic MWF exposure and cancer of the oesophagus, liver and prostate. These results provide further evidence that exposure to metalworking fluids causes cancer among workers in automobile manufacturing, and that risks of several digestive cancers, prostate cancer and leukaemia, may persist at current levels of exposure to water-based metalworking fluids.
Descriptors (primary) mortality; cutting fluids; risk factors; motor vehicle industry; cancer
Descriptors (secondary) rectal cancer; leukaemia; oesophageal carcinoma; brain cancer; pancreatic diseases; skin cancer; frequency rates; prostatic cancer; liver cancer; limitation of exposure; cohort study; long-term study; poisson distribution; gastrointestinal cancer
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Metal production and metalworking
Broad subject area(s) Industries and occupations
Chemical safety
Browse category(ies) Motor vehicle manufacturing industry