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Document ID (ISN)101951
CIS number 03-743
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 2001
Convention or series no.
Author(s) Hagmar L., T÷rnqvist M., Nordander C., RosÚn I., Bruze M., Kautiainen A., Magnusson A.L., Malmberg B., Aprea P., Granath F., Axmon A.
Title Health effects of occupational exposure to acrylamide using hemoglobin adducts as biomarkers of internal dose
Bibliographic information Aug. 2001, Vol.27, No.4, p.219-226. Illus. 23 ref.
Abstract A total of 210 workers at a tunnel construction site exposed for about two months to a chemical-grouting agent containing acrylamide and N-methylolacrylamide underwent a health examination. Blood samples were drawn for the analysis of haemoglobin (Hb) adducts of acrylamide. 50 workers claiming recently-developed or deteriorating symptoms of the peripheral nervous system (PNS) were referred to a neurophysiological examination. Workers with Hb-adduct levels exceeding 0.3nmol/g globin attended follow-up examinations 6, 12, and 18 months after exposure cessation. 47 workers had Hb-adduct levels within the normal background range (0.02-0.07nmol/g globin), while the remaining 163 had increased levels up to 17.7nmol/g globin. Clear-cut dose-response associations were found between the Hb-adduct levels and PNS symptoms. However, the PNS symptoms were generally mild and reversible in almost all cases.
Descriptors (primary) neurotoxic effects; tunnelling; acrylamide; construction industry; exposure evaluation
Descriptors (secondary) haemoglobin; symptoms; medical examinations; dose-response relationship; determination in blood; diseases of peripheral nervous system
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the nervous system
Amides
Construction industry and civil engineering
Exposure evaluation