|Document ID (ISN)||101951|
|ISSN - Serial title
||0355-3140 - Scandinavian Journal of Work, Environment and Health
|Convention or series no.
||Hagmar L., T÷rnqvist M., Nordander C., RosÚn I., Bruze M., Kautiainen A., Magnusson A.L., Malmberg B., Aprea P., Granath F., Axmon A.
||Health effects of occupational exposure to acrylamide using hemoglobin adducts as biomarkers of internal dose
||Aug. 2001, Vol.27, No.4, p.219-226. Illus. 23 ref.
||A total of 210 workers at a tunnel construction site exposed for about two months to a chemical-grouting agent containing acrylamide and N-methylolacrylamide underwent a health examination. Blood samples were drawn for the analysis of haemoglobin (Hb) adducts of acrylamide. 50 workers claiming recently-developed or deteriorating symptoms of the peripheral nervous system (PNS) were referred to a neurophysiological examination. Workers with Hb-adduct levels exceeding 0.3nmol/g globin attended follow-up examinations 6, 12, and 18 months after exposure cessation. 47 workers had Hb-adduct levels within the normal background range (0.02-0.07nmol/g globin), while the remaining 163 had increased levels up to 17.7nmol/g globin. Clear-cut dose-response associations were found between the Hb-adduct levels and PNS symptoms. However, the PNS symptoms were generally mild and reversible in almost all cases.
||neurotoxic effects; tunnelling; acrylamide; construction industry; exposure evaluation
||haemoglobin; symptoms; medical examinations; dose-response relationship; determination in blood; diseases of peripheral nervous system
||D - Periodical articles
|Country / State or Province||Sweden|
||Toxic and dangerous substances
|Broad subject area(s)
||Diseases of the nervous system
Construction industry and civil engineering