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Document ID (ISN)101718
CIS number 03-741
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2002
Convention or series no.
Author(s) Apostoli P., Sarnico M., Bavazzano P., Bartoli D.
Title Arsenic and porphyrins
Bibliographic information Sep. 2002, Vol.42, No.3, p.180-187. Illus. 26 ref.
Abstract To evaluate the possible effect of arsenic and of its compounds on the urinary excretion of porphyrin homologues, the following substances were determined in the urine of 86 art glass workers exposed to arsenic and its compounds and from 54 non-exposed controls: total porphyrins and their homologues (copro, penta, hexa, hepta, uroporphyrins) and the following arsenic species: trivalent and pentavalent arsenic, monomethyl arsonic acid, dimethyl arsinic acid and arsenobetaine. A significant increase in the excretion of penta and uroporphyrins was found for workers exposed to arsenic. The best correlation with urinary porphyrin excretion was found with trivalent arsenic. The increase of urinary excretion for some porphyrin homologues is consistent with the inhibition by arsenic of uro-decarboxylase in the haeme biosynthesis pathway. The determination of urinary porphyrin homologues could be useful to assess some early effects of arsenic exposure and to demonstrate possible individual susceptibility to the element.
Descriptors (primary) arsenic and compounds; porphyrins; exposure tests; glass blowing; urinary excretion
Descriptors (secondary) small enterprises; arsenic; exposure evaluation; methylarsonic acid; porphyrin metabolism; individual susceptibility; determination in urine; case-control study
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Arsenic and compounds
Inorganic substances