|Document ID (ISN)||101705|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||Brüning T., Pesch B., Wiesenhütter B., Rabstein S., Lammert M., Baumüller A., Bolt H.M.
||Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case-control study in Arnsberg, Germany
||Mar. 2003, Vol.43, No.3, p.274-285. 42 ref.
||Findings of German studies on the relation between exposure to high levels of trichloroethylene (TRI) and renal cell cancer (RCC) are contradictory. A hospital-based case-control study with 134 RCC cases and 401 controls was conducted in order to re-evaluate the risk due to TRI in the German region of Arnsberg, which had been estimated in a previous study. Exposure was self-assessed to compare these studies. Job history was analysed using expert-based exposure information. The logistic regression results adjusted for age, sex and smoking confirmed a TRI- related RCC risk. Using the CAREX database for a comparison of industries with and without TRI exposure, a significant excess risk was estimated for the longest held job in TRI-exposing industries (odds ratio (OR) 1.80). The OR in metal degreasing activities was 5.57. Self-reported narcotic symptoms, indicative of peak exposures, were also associated with an excess risk (OR=3.71). The study supports the human nephro-carcinogenicity of trichloroethylene.
||trichloroethylene; risk factors; renal cancer
||subjective assessment; Germany; symptoms; hazard evaluation; exposure evaluation; case-control study; frequency rates; narcotic effects; nephrotoxic effects; statistical evaluation; medical examinations; computerized data bases; hospitals
||D - Periodical articles
|Country / State or Province||Germany|
|Broad subject area(s)
Diseases of the kidney and the urinary system