| Document ID (ISN) | 101705 |
| CIS number |
03-759 |
| ISSN - Serial title |
0271-3586 - American Journal of Industrial Medicine |
| Year |
2003 |
| Convention or series no. |
|
| Author(s) |
Brüning T., Pesch B., Wiesenhütter B., Rabstein S., Lammert M., Baumüller A., Bolt H.M. |
| Title |
Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case-control study in Arnsberg, Germany |
| Bibliographic information |
Mar. 2003, Vol.43, No.3, p.274-285. 42 ref. |
| Abstract |
Findings of German studies on the relation between exposure to high levels of trichloroethylene (TRI) and renal cell cancer (RCC) are contradictory. A hospital-based case-control study with 134 RCC cases and 401 controls was conducted in order to re-evaluate the risk due to TRI in the German region of Arnsberg, which had been estimated in a previous study. Exposure was self-assessed to compare these studies. Job history was analysed using expert-based exposure information. The logistic regression results adjusted for age, sex and smoking confirmed a TRI- related RCC risk. Using the CAREX database for a comparison of industries with and without TRI exposure, a significant excess risk was estimated for the longest held job in TRI-exposing industries (odds ratio (OR) 1.80). The OR in metal degreasing activities was 5.57. Self-reported narcotic symptoms, indicative of peak exposures, were also associated with an excess risk (OR=3.71). The study supports the human nephro-carcinogenicity of trichloroethylene. |
| Descriptors (primary) |
trichloroethylene; risk factors; renal cancer |
| Descriptors (secondary) |
subjective assessment; Germany; symptoms; hazard evaluation; exposure evaluation; case-control study; frequency rates; narcotic effects; nephrotoxic effects; statistical evaluation; medical examinations; computerized data bases; hospitals |
| Document type |
D - Periodical articles |
| Country / State or Province | Germany |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Diseases of the kidney and the urinary system
Halogenated hydrocarbons
|
