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Document ID (ISN)101679
CIS number 03-740
ISSN - Serial title 0170-2327 - Ergo-Med
Year 2002
Convention or series no.
Author(s) Jung D., Böttiger A.
Title Mutagenicity and teratogenicity studies during the handling of cytostatic drugs
Original title Studien zur Mutagenität und Teragenität beim Umgang mit Zytostatika [in German]
Bibliographic information Nov.-Dec. 2002, Vol.26, No.6, p.162-166. Illus. 3 ref.
Abstract Three studies involving hospital pharmacists were carried out in order to establish mutagenic and teratogenic hazards during the handling of cytostatic drugs. Sister chromatid exchanges, breaks in DNA strands, alkyl guanidine transferase levels and mitosis levels were evaluated. Under working conditions that include the most recent technologies (work in laminar flow safety cabinets), no significant differences were observed between exposed and non-exposed groups.
Descriptors (primary) mutagens; antineoplastic drugs; teratogenic effects; hospitals; manual handling
Descriptors (secondary) mitosis; DNA; expectant mothers; case-control study; chromosome changes; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceGermany
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Health care services
Genetic factors in reaction to exposures