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Document ID (ISN)101641
CIS number 03-821
ISBN(s) 0773-6347-31
Year 2002
Convention or series no. ECETOC Monograph No.31
Title Guidance on evaluation of reproductive toxicity data
Bibliographic information European Centre for Ecotoxicology and Toxicology of Chemicals, Avenue E. Van Nieuwenhuyse 4, Bte. 6, 1160 Bruxelles, Belgium, Feb. 2002. 136p. Illus. 87 ref. Price : EUR 50.00.
Abstract This monograph provides guidance in the form of a structured approach for the interpretation of reproductive toxicity data. The approach is illustrated through the use of examples from several fertility and developmental toxicity studies. The possible role of maternal toxicity in the interpretation of the study findings is also taken into account. Contents: overview of the reproductive process; review of test guidelines; effects on embryo-foetal development; effects on fertility and reproduction; structured approach to evaluation of reproductive toxicity data. Appendices include: test guideline comparison; summary data sets for example substances.
Descriptors (primary) antifertility effects; toxicology; teratogenic effects; hazard evaluation; harmful substances
Descriptors (secondary) literature survey; criteria document; evaluation of results
Document type F - Information notes, codes of practice, standards
Country / State or ProvinceBelgium
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures
Risk evaluation