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Document ID (ISN)101581
CIS number 03-758
ISSN - Serial title 0105-1873 - Contact Dermatitis
Year 2003
Convention or series no.
Author(s) Frick M., Isaksson M., Bj÷rkner B., HindsÚn M., PontÚn A., Bruze M.
Title Occupational allergic contact dermatitis in a company manufacturing boards coated with isocyanate lacquer
Bibliographic information May 2003, Vol.48, No.5, p.255-260. 16 ref.
Abstract Following the introduction of a lacquer based on diphenylmethane-4,4'-diisocyanate at a company producing flooring laminate boards, there was an outbreak of work-related skin lesions among workers. In five workers, patch testing was performed with a standard series, an isocyanate series and products present in the work environment. Among workers tested with the lacquer, contact allergy was found with concurrent reactions to 4,4'-diaminodiphenylmethane (MDA). Occupational contact with isocyanates should not be exclusively focused upon respiratory hazards, as this report shows that skin contamination probably increases the risk of developing contact allergy to isocyanates and isocyanate-related substances. When aiming at diagnosing contact allergy to isocyanates, it is desirable to perform a late reading, as positive reactions appear late. MDA appears to be a good marker for isocyanate hypersensitivity.
Descriptors (primary) diphenylmethane diisocyanate; lacquers; dermatitis; flooring
Descriptors (secondary) allergens; methylenedianiline; case study; hypersensitivity; eczema; delayed effects; skin tests; skin allergies
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Skin diseases
Isocyanates
Cyano compounds