| Document ID (ISN) | 101516 |
| CIS number |
03-753 |
| ISSN - Serial title |
1351-0711 - Occupational and Environmental Medicine |
| Year |
2003 |
| Convention or series no. |
|
| Author(s) |
Maroni M., Mocci F., Visentin S., Preti G., Fanetti A.C. |
| Title |
Periportal fibrosis and other liver ultrasonography findings in vinyl chloride workers |
| Bibliographic information |
Jan. 2003, Vol.60, No.1, p.60-65. 42 ref. |
| Abstract |
To investigate the presence of liver lesions and their relationship with vinyl chloride exposure, a liver ultrasonography examination was conducted in 757 workers involved in the production of vinyl chloride and PVC. The study involved an assessment of past and present vinyl chloride exposure of each worker, the collection of personal, lifestyle and health history data, routine liver function tests and liver ultrasonography. No cases of liver malignancies were detected. Angiomas and liver cysts were found with occurrence frequencies comparable to that of the general population. However, cases of hepatomegalia (34.7%), steatosis (31.8%) and periportal fibrosis (16.0%) were observed. Periportal fibrosis was shown to be associated with vinyl chloride exposure, but only when maximum exposure in the subject's history had been at least 200ppm as a yearly average; no effects were observed at 50ppm or below. |
| Descriptors (primary) |
hepatic damage; risk factors; vinyl chloride |
| Descriptors (secondary) |
polyvinyl chloride; cysts; angiomas; ultrasonic examinations; hepatomegalia; exposure evaluation; liver function tests; liver fibrosis |
| Document type |
D - Periodical articles |
| Country / State or Province | Italy |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Liver diseases
Halogenated hydrocarbons
|
