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Document ID (ISN)101481
CIS number 03-303
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2003
Convention or series no.
Author(s) Grasel S.S., Alves V.A.F., da Silva C.S., Cruz O.L.M.., Almeida E.R., de Oliveira E.
Title Clinical and histopathological changes of the nasal mucosa induced by occupational exposure to sulphuric acid mists
Bibliographic information June 2003, Vol.60, No.6, p.395-402. Illus. 20 ref.
Internet access 03-0303.pdf [in English]
Abstract The aim of this study was to assess potential alterations of the nasal mucosa by clinical and histopathological evaluation of workers exposed to sulfuric acid mists at anodizing plants and to correlate the findings with duration of exposure and sulfuric acid concentrations in the air. A total of 52 workers from five plants underwent a clinical evaluation (standard questionnaire, clinical, and ear, nose and throat examination including nasal endoscopy). For the histopathological study, 20 of the 52 subjects (study group) were randomly selected, as well as 11 unexposed subjects (control group), matched by sex, age and smoking habit. Nasal biopsy specimens were obtained from the anterior septum mucosa. The histopathological study revealed squamous metaplasia in 79% and atypia in 5% of the study group samples. No association was found between exposure duration and the clinical and histopathological variables, but a significant association was found between sulfuric acid concentrations higher than 200µg/m3 and pale mucosal patches and ulcerations in the exposed subjects. Logistic regression analysis showed that the exposed subjects had a fivefold risk of developing atypia compared with the unexposed subjects. The risk for histopathological lesions increased with higher sulfuric acid concentrations in the air, revealing an exposure-response relation.
Descriptors (primary) histological effects; anodizing; sulfuric acid; mists; mucous membranes; nose
Descriptors (secondary) case-control study; histopathology; length of exposure; ulceration of the nasal mucosa; determination in air; endoscopy; dose-response relationship
Document type D - Periodical articles
Country / State or ProvinceBrazil
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Inorganic sulfur compounds
Surface treatment