| Document ID (ISN) | 101281 |
| CIS number |
03-300 |
| ISSN - Serial title |
0003-4878 - Annals of Occupational Hygiene |
| Year |
2000 |
| Convention or series no. |
|
| Author(s) |
Browne K., Gee B.L. |
| Title |
Asbestos exposure and laryngeal cancer |
| Bibliographic information |
June 2000, Vol.44, No.4, p.239-250. 101 ref. |
| Abstract |
Studies of workers exposed to asbestos that included data on laryngeal disease are reviewed, together with studies of laryngeal cancers with epidemiological or experimental evidence of associated exposures. Confounding factors of smoking and alcohol intake create major difficulties for the identification of any asbestos or other occupational effects. Smoking and alcohol are independently and synergistically associated with large increases in the relative risk of laryngeal cancer. However, few studies provide details of either habit. Among 24 prospective studies for which a standardized mortality ratio was available, there was a clear excess risk only in one case. In 17 retrospective studies, only two showed a significantly increased risk. Evidence from animal experiments, studies of associations with pleural plaques, and autopsy findings also appear negative or inconclusive. The evidence does not indicate that asbestos exposure increases the risk of laryngeal cancer. |
| Descriptors (primary) |
occupational diseases; asbestos; risk factors; hazard evaluation; laryngeal cancer |
| Descriptors (secondary) |
literature survey; pleural thickening; alcoholism; smoking; frequency rates; confounding factors; animal experiments; long-term study; autopsy; mortality |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
Occupational medicine, epidemiology
|
| Browse category(ies) |
Asbestos
Risk evaluation
Alcohol and drug abuse
Diseases of the respiratory system (except for pneumoconiosis & similar)
|
