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Document ID (ISN)101281
CIS number 03-300
ISSN - Serial title 0003-4878 - Annals of Occupational Hygiene
Year 2000
Convention or series no.
Author(s) Browne K., Gee B.L.
Title Asbestos exposure and laryngeal cancer
Bibliographic information June 2000, Vol.44, No.4, p.239-250. 101 ref.
Abstract Studies of workers exposed to asbestos that included data on laryngeal disease are reviewed, together with studies of laryngeal cancers with epidemiological or experimental evidence of associated exposures. Confounding factors of smoking and alcohol intake create major difficulties for the identification of any asbestos or other occupational effects. Smoking and alcohol are independently and synergistically associated with large increases in the relative risk of laryngeal cancer. However, few studies provide details of either habit. Among 24 prospective studies for which a standardized mortality ratio was available, there was a clear excess risk only in one case. In 17 retrospective studies, only two showed a significantly increased risk. Evidence from animal experiments, studies of associations with pleural plaques, and autopsy findings also appear negative or inconclusive. The evidence does not indicate that asbestos exposure increases the risk of laryngeal cancer.
Descriptors (primary) occupational diseases; asbestos; risk factors; hazard evaluation; laryngeal cancer
Descriptors (secondary) literature survey; pleural thickening; alcoholism; smoking; frequency rates; confounding factors; animal experiments; long-term study; autopsy; mortality
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Asbestos
Risk evaluation
Alcohol and drug abuse