|Document ID (ISN)||101154|
|ISSN - Serial title
||1076-2752 - Journal of Occupational and Environmental Medicine
|Convention or series no.
||Cocco P., Rice C.H., Chen J.Q., McCawley M., McLaughlin J.K., Dosemeci M.
||Non-malignant respiratory diseases and lung cancer among Chinese workers exposed to silica
||June 2000, Vol.42, No.6, p.639-644. 19 ref.
||To explore whether a medical history for non-malignant respiratory disease contributes to an increased lung cancer risk among workers exposed to silica, data from a nested case-control study involving 29 dusty workplaces in China were analysed. The study population consisted of 316 lung cancer cases and 1356 controls matched by facility type and decade of birth. Smoking was the main risk factor for both lung cancer and chronic bronchitis. Lung cancer risk showed a modest association with silicosis and with cumulative silica exposure, which did not vary by history of previous pulmonary tuberculosis. Among subjects without a medical history for chronic bronchitis or asthma, lung cancer risk was associated with silicosis (odds ratio (OR) 1.6). Among subjects with a medical history for chronic bronchitis or asthma, lung cancer risk was associated with neither silicosis (subjects with chronic bronchitis: OR 0.6; subjects with asthma: OR 0.4) nor with silica exposure.
||silica; respiratory diseases; risk factors; dust; lung cancer
||China; anamnesis; smoking; bronchitis; frequency rates; silicosis; hazard evaluation; case-control study; confounding factors; asthma
||D - Periodical articles
|Country / State or Province||China; Italy; USA|
|Broad subject area(s)
||Diseases of the respiratory system (except for pneumoconiosis & similar)