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Document ID (ISN)101154
CIS number 03-296
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2000
Convention or series no.
Author(s) Cocco P., Rice C.H., Chen J.Q., McCawley M., McLaughlin J.K., Dosemeci M.
Title Non-malignant respiratory diseases and lung cancer among Chinese workers exposed to silica
Bibliographic information June 2000, Vol.42, No.6, p.639-644. 19 ref.
Abstract To explore whether a medical history for non-malignant respiratory disease contributes to an increased lung cancer risk among workers exposed to silica, data from a nested case-control study involving 29 dusty workplaces in China were analysed. The study population consisted of 316 lung cancer cases and 1356 controls matched by facility type and decade of birth. Smoking was the main risk factor for both lung cancer and chronic bronchitis. Lung cancer risk showed a modest association with silicosis and with cumulative silica exposure, which did not vary by history of previous pulmonary tuberculosis. Among subjects without a medical history for chronic bronchitis or asthma, lung cancer risk was associated with silicosis (odds ratio (OR) 1.6). Among subjects with a medical history for chronic bronchitis or asthma, lung cancer risk was associated with neither silicosis (subjects with chronic bronchitis: OR 0.6; subjects with asthma: OR 0.4) nor with silica exposure.
Descriptors (primary) silica; respiratory diseases; risk factors; dust; lung cancer
Descriptors (secondary) China; anamnesis; smoking; bronchitis; frequency rates; silicosis; hazard evaluation; case-control study; confounding factors; asthma
Document type D - Periodical articles
Country / State or ProvinceChina; Italy; USA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)