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CISDOC database

Document ID (ISN)101153
CIS number 03-183
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2000
Convention or series no.
Author(s) Caccappolo E., Kipen H., Kelly-McNeil K., Knasko S., Hamer R.M., Natelson B., Fiedler N.
Title Odor perception: Multiple chemical sensitivities, chronic fatigue and asthma
Bibliographic information June 2000, Vol.42, No.6, p.629-638. Illus. 28 ref.
Abstract Patients with multiple chemical sensitivities (MCS) often report heightened sensitivity to odours. Odour detection thresholds to phenyl ethyl alcohol (PEA) and pyridine (PYR) were evaluated for 33 MCS subjects, 13 chronic fatigue syndrome subjects, 16 asthmatic subjects and 27 healthy controls. Odour identification ability (based on University of Pennsylvania Smell Identification test results) and ratings in response to four supra-threshold concentrations of PEA and PYR were also assessed. Odour detection thresholds for PTA and PYR and odour identification ability were equivalent for all groups; however, when exposed to supra-threshold concentrations of PEA, MCS subjects reported significantly more trigeminal symptoms and lower aesthetic ratings for the substance. No group differences were found in response to supra-threshold concentrations of PYR.
Descriptors (primary) asthma; sensitizers; individual susceptibility; odour threshold; fatigue
Descriptors (secondary) pyridine; symptoms; trigeminal nerve; aromatic alcohols; case-control study
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Multiple chemical sensitivities
Diseases of other sense organs (other than the eye and the ears)