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Document ID (ISN)101150
CIS number 03-58
Year 2002
Convention or series no. Fiche toxicologique No.242
Author(s) Bonnard N., Brondeau M.T., Falcy M., Jargot D., Protois J.C., Schneider O.
Title Methyl tert-butyl oxide (MTBE)
Original title Oxyde de tert-butyle et de mÚthyle (MTBE) [in French]
Bibliographic information Institut national de recherche et de sÚcuritÚ, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, CD-ROM CD 613, 2002. 6p. Illus. 31 ref.
Abstract Chemical safety information sheet. Synonyms: 2-methoxy-2-methylpropane; MTBE. The acute toxicity of MTBE is low. At high concentrations, it causes hypoactivity, depression of the central nervous system and ataxia. It is a moderate skin irritant and a weak eye irritant. It causes respiratory irritation. It is not a skin sensitizer. There is very limited data on human chronic toxicity. At high repeated concentrations in rats, the substance causes damage to the central nervous system, irritation of the gastro-intestinal and respiratory tracts, slight modifications of serum parameters and chronic nephropathy among males. Since most in vitro or in vivo genotoxicity tests are negative, MTBE is presumed to be non-mutagenic. It has no effects on reproductive health. Exposure limits: USA (ACGIH): TWA = 40ppm; Germany (MAK): TWA = 180mg/m3 or 50ppm. EEC number and mandatory labelling codes: No.216-653-1; F, Xi; R11, R38, S9, S16, S24. Complete datasheet collection on CD-ROM analysed under CIS 02-1407.
Descriptors (primary) threshold limit values; methyl t-butyl ether; France
Descriptors (secondary) dangerous substances; data sheet; fire hazards; diseases of central nervous system; toxicology; transport; explosion hazards; labelling; limitation of exposure; waste disposal; first aid; personal protective equipment; animal experiments; in vitro experiments; spills; health hazards; legislation; sampling and analysis; irritants
Document type B - Chemical safety information sheets
Country / State or ProvinceFrance
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Ethers
Occupational exposure limits