|Document ID (ISN)||101150|
|Convention or series no.
||Fiche toxicologique No.242
||Bonnard N., Brondeau M.T., Falcy M., Jargot D., Protois J.C., Schneider O.
||Methyl tert-butyl oxide (MTBE)
||Oxyde de tert-butyle et de mÚthyle (MTBE) [in French]|
||Institut national de recherche et de sÚcuritÚ, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, CD-ROM CD 613, 2002. 6p. Illus. 31 ref.
||Chemical safety information sheet. Synonyms: 2-methoxy-2-methylpropane; MTBE. The acute toxicity of MTBE is low. At high concentrations, it causes hypoactivity, depression of the central nervous system and ataxia. It is a moderate skin irritant and a weak eye irritant. It causes respiratory irritation. It is not a skin sensitizer. There is very limited data on human chronic toxicity. At high repeated concentrations in rats, the substance causes damage to the central nervous system, irritation of the gastro-intestinal and respiratory tracts, slight modifications of serum parameters and chronic nephropathy among males. Since most in vitro or in vivo genotoxicity tests are negative, MTBE is presumed to be non-mutagenic. It has no effects on reproductive health. Exposure limits: USA (ACGIH): TWA = 40ppm; Germany (MAK): TWA = 180mg/m3 or 50ppm. EEC number and mandatory labelling codes: No.216-653-1; F, Xi; R11, R38, S9, S16, S24. Complete datasheet collection on CD-ROM analysed under CIS 02-1407.
||threshold limit values; methyl t-butyl ether; France
||dangerous substances; data sheet; fire hazards; diseases of central nervous system; toxicology; transport; explosion hazards; labelling; limitation of exposure; waste disposal; first aid; personal protective equipment; animal experiments; in vitro experiments; spills; health hazards; legislation; sampling and analysis; irritants
||B - Chemical safety information sheets
|Country / State or Province||France|
||Toxic and dangerous substances
|Broad subject area(s)
Occupational exposure limits