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Document ID (ISN)101071
CIS number 03-277
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2000
Convention or series no.
Author(s) Ryan J.J., Schecter A.
Title Exposure of Russian phenoxy herbicide producers to dioxins
Bibliographic information Sep. 2000, Vol.42, No.9, p.861-870. Illus. 36 ref.
Abstract Blood samples of workers who worked during the 1960s at a phenoxy herbicide plant in the Bashkortostan region of Russia were collected in 1992 and analysed by GC-MS. 34 workers who manufactured 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) had median blood lipid 2,3,7,8-tetrachlorodibenzo p-dioxin (TCDD) concentrations of 166ng/kg and 1,2,3,7,8-pentachloro-p-dioxin (PnCDD) levels of 52ng/kg. These values are 10 to 30 times higher than contemporary normal levels from the Bashkortostan region and were at least 10-fold higher in the 1960s. Six workers who produced the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) also had elevated levels in 1992, with PnCDD levels higher than those of TCDD. Children of some of the workers and factory administrative personnel also had blood levels of TCDD higher than most general population groups from other parts of Russia or from other countries. No correlation was found between chloracne status in 1965 to 1967 and TCDD or toxic equivalent blood lipid concentrations in 1992. These phenoxy herbicide workers appear to have some the highest dioxins levels of any cohort studied to date.
Descriptors (primary) herbicides; dichlorophenoxyacetic acid; chemical plant; dioxins; trichlorophenoxyacetic acid
Descriptors (secondary) Russian Federation; tetrachlorodibenzodioxin; chloracne; determination in blood; cohort study; long-term study; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceCanada; USA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Heterocyclic compounds
Agricultural chemicals