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Document ID (ISN)101005
CIS number 03-329
Year 2003
Convention or series no. ECETOC Technical Report No.86
Title Derivation of assessment factors for human health risk assessment
Bibliographic information European Centre for Ecotoxicology and Toxicology of Chemicals, Avenue E. Van Nieuwenhuyse 4, Bte. 6, 1160 Bruxelles, Belgium, Feb. 2003. 86p. 32 ref.
Abstract The human health risk of chemical substances is generally assessed by extrapolation from heterogeneous animal study data to man. In this report, the extrapolation elements used in the process are reviewed in the context of the most recent relevant data. In cases where appropriate substance-specific information is lacking, guidance is provided on the derivation of possible numerical values to account for the uncertainties in defining a safe dose for humans. Contents: background and scope; elements of extrapolation (establishment of the "no observed adverse effect level" (NOAEL), duration of exposure, route to extrapolation, inter-species and intra-species extrapolation); recommended default assessment factors.
Descriptors (primary) toxicology; health hazards; extrapolation animal man; hazard evaluation
Descriptors (secondary) report; permissible levels; description of technique; biological effects; animal experiments
Document type E - Books, reports, proceedings
Country / State or ProvinceBelgium
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Risk evaluation