| Document ID (ISN) | 101005 |
| CIS number |
03-329 |
| Year |
2003 |
| Convention or series no. |
ECETOC Technical Report No.86
|
| Title |
Derivation of assessment factors for human health risk assessment |
| Bibliographic information |
European Centre for Ecotoxicology and Toxicology of Chemicals, Avenue E. Van Nieuwenhuyse 4, Bte. 6, 1160 Bruxelles, Belgium, Feb. 2003. 86p. 32 ref. |
| Abstract |
The human health risk of chemical substances is generally assessed by extrapolation from heterogeneous animal study data to man. In this report, the extrapolation elements used in the process are reviewed in the context of the most recent relevant data. In cases where appropriate substance-specific information is lacking, guidance is provided on the derivation of possible numerical values to account for the uncertainties in defining a safe dose for humans. Contents: background and scope; elements of extrapolation (establishment of the "no observed adverse effect level" (NOAEL), duration of exposure, route to extrapolation, inter-species and intra-species extrapolation); recommended default assessment factors. |
| Descriptors (primary) |
toxicology; health hazards; extrapolation animal man; hazard evaluation |
| Descriptors (secondary) |
report; permissible levels; description of technique; biological effects; animal experiments |
| Document type |
E - Books, reports, proceedings |
| Country / State or Province | Belgium |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Risk evaluation
|
