| Document ID (ISN) | 101004 |
| CIS number |
03-328 |
| ISBN(s) |
0773-6347-85 |
| Year |
2002 |
| Convention or series no. |
ECETOC Technical Report No.85
|
| Title |
Recognition of, and differentiation between, adverse and non-adverse effects in toxicology studies |
| Bibliographic information |
European Centre for Ecotoxicology and Toxicology of Chemicals, Avenue E. Van Nieuwenhuyse 4, Bte. 6, 1160 Bruxelles, Belgium, Dec. 2002. 56p. 46 ref. |
| Abstract |
One of the most important quantitative outputs from toxicity studies is the identification of the highest exposure level that does not cause adverse effects to human health. This report reviews the criteria that could be used to guide the consistent interpretation of toxicity studies, and in particular the differentiation between adverse and non-adverse effects. Contents: background and scope; definitions and approaches; interpretation of toxicological data; consequences of using the "no observed effect level" (NOEL) and "no observed adverse effect level" (NOAEL) approaches in risk assessment; conclusions, including a proposed set of coherent definitions. |
| Descriptors (primary) |
toxicology; health hazards; hazard evaluation |
| Descriptors (secondary) |
report; description of technique; biological effects; permissible levels |
| Document type |
E - Books, reports, proceedings |
| Country / State or Province | Belgium |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Toxicology
Risk evaluation
|
