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CISDOC database

Document ID (ISN)101004
CIS number 03-328
ISBN(s) 0773-6347-85
Year 2002
Convention or series no. ECETOC Technical Report No.85
Title Recognition of, and differentiation between, adverse and non-adverse effects in toxicology studies
Bibliographic information European Centre for Ecotoxicology and Toxicology of Chemicals, Avenue E. Van Nieuwenhuyse 4, Bte. 6, 1160 Bruxelles, Belgium, Dec. 2002. 56p. 46 ref.
Abstract One of the most important quantitative outputs from toxicity studies is the identification of the highest exposure level that does not cause adverse effects to human health. This report reviews the criteria that could be used to guide the consistent interpretation of toxicity studies, and in particular the differentiation between adverse and non-adverse effects. Contents: background and scope; definitions and approaches; interpretation of toxicological data; consequences of using the "no observed effect level" (NOEL) and "no observed adverse effect level" (NOAEL) approaches in risk assessment; conclusions, including a proposed set of coherent definitions.
Descriptors (primary) toxicology; health hazards; hazard evaluation
Descriptors (secondary) report; description of technique; biological effects; permissible levels
Document type E - Books, reports, proceedings
Country / State or ProvinceBelgium
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Toxicology
Risk evaluation