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Document ID (ISN)100998
CIS number 02-1806
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2002
Convention or series no.
Author(s) Daftarian H.S., Lushniak B.D., Reh C.M., Lewis D.M.
Title Evaluation of self-reported skin problems among workers exposed to toluene diisocyanate (TDI) at a foam manufacturing facility
Bibliographic information Dec. 2002, Vol.44, No.12, p.1197-1202. 30 ref.
Abstract To investigate the dermal effects of toluene diisocyanate (TDI), a cross-sectional study was carried out at a polyurethane foam manufacturing plant. A totla of 114 workers completed a medical questionnaire and provided blood for antibody testing to TDI and other allergens. A subset of participants reporting skin symptoms underwent skin patch testing to a standard diisocyanate panel. Production line workers were more likely to report skin problems than those working in non-production areas (OR 2.66). Age, sex and duration of employment at the plant were comparable among participants working in production and non-production areas. Specific IgG antibody to TDI was detected in two individuals, while none of the samples demonstrated specific IgE antibody to TDI. Of the 26 workers who underwent skin patch testing, none developed reactions to the diisocyanate allergens. These results suggest that skin symptoms represent an irritant rather than an immunological reaction to TDI, or to an unidentified allergen present in the foam.
Descriptors (primary) polyurethanes; tolylene diisocyanate; motor vehicle industry; skin allergies; expanded plastics
Descriptors (secondary) allergens; irritants; immunoglobulins; antibodies; determination in blood; questionnaire survey; cross-sectional study; skin tests; symptoms
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Motor vehicle manufacturing industry
Cyano compounds
Skin diseases