| Document ID (ISN) | 100971 |
| CIS number |
02-1805 |
| ISSN - Serial title |
0271-3586 - American Journal of Industrial Medicine |
| Year |
2002 |
| Convention or series no. |
|
| Author(s) |
Rinsky R.A., Hornung R.W., Silver S.R., Tseng C.Y. |
| Title |
Benzene exposure and hematopoietic mortality: A long-term epidemiologic risk assessment |
| Bibliographic information |
Dec 2002, Vol.42, No.6, p.474-480. 23 ref. |
| Abstract |
Previous studies of a cohort of rubber industry workers indicated an association between benzene exposure and excess mortality from leukaemia and multiple myeloma. To determine whether risks remain elevated since plant shutdown, follow-up was extended from 1981 through 1996. Risks were evaluated using standardized mortality ratios (SMR) and generalized Cox proportional hazards regression models. Five new leukaemia cases were observed in benzene-exposed white males, but the summary SMR for this group declined from 3.37 to 2.56. In regression models, cumulative exposure was significantly associated with elevated relative risks for leukaemia mortality. Four new multiple myeloma deaths occurred, three of which were in workers judged to be unexposed. These findings reaffirm the leukaemogenic effects of benzene exposure and suggest that excess risk diminishes with time. |
| Descriptors (primary) |
rubber industry; leukaemia; benzene; risk factors; myeloma; cancer; bone marrow diseases |
| Descriptors (secondary) |
mortality; epidemiology; hazard evaluation; bone marrow cytology; long-term study; statistical evaluation; cohort study |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Rubber industry
Leukaemia
Blood diseases
Aromatic hydrocarbons
|
