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Document ID (ISN)100724
CIS number 02-1788
ISSN - Serial title 0019-8366 - Industrial Health
Year 2002
Convention or series no.
Author(s) Otsuka F.
Title Gene expression assay for hazard assessment of chemicals
Bibliographic information Apr. 2002, Vol.40, No.2, p.113-120. Illus. 49 ref.
Abstract Recent progress in the understanding of gene expression systems provides evidence that many industrial chemicals affect the transcriptional machineries directly or indirectly, and gene expression is now recognized as one of the main targets of many chemicals. In view of the increasing number of man-made chemicals, it is therefore necessary to establish a reliable gene expression assay with rapidity and high sensitivity. Among various gene expression assays, the so-called reporter assay is now accepted as a suitable tool to assess hazardous effects of chemicals on gene expression. This article focuses on the principle and applications of the reporter assay in research on endocrine disrupters.
Descriptors (primary) DNA; harmful substances; endocrine effects; genetic effects; exposure evaluation
Descriptors (secondary) description of technique; hormones
Document type D - Periodical articles
Country / State or ProvinceJapan
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures
Exposure evaluation