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CISDOC database

Document ID (ISN)100528
CIS number 02-1544
Year 1997
Convention or series no. Toxikologische Bewertung Nr.78
Title 4-Chlorophenyl isocyanate
Original title 4-Chlorphenylisocyanat [in German]
Bibliographic information Berufsgenossenschaft der chemischen Industrie, Postfach 10 14 80, 69004 Heidelberg, Germany, Jan. 1997. 23p. 20 ref.
Abstract Repeated contact with 4-chlorophenyl isocyanate causes itchy erythema and dryness of the skin. The substance irritates the eyes. Animal experiments show high toxicity upon inhalation exposure and harmful to toxic effects upon acute oral and dermal administration. No genotoxic effect has been observed. A comparison of the toxic effects of 4-chlorophenyl isocyanate, phenyl isocyanate and 4-isopropylphenyl isocyanate in humans and animals is also presented. In humans, the only toxic effect described is an itchy erythema after repeated contact with chlorophenyl isocyanate.
Descriptors (primary) 4-chlorophenyl isocyanate; Germany; pharmaceutical industry; pesticides; toxicity evaluation; isocyanates
Descriptors (secondary) toxic effects; literature survey; criteria document; erythema; animal experiments; irritants
Document type B - Chemical safety information sheets
Country / State or ProvinceGermany
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Isocyanates
Cyano compounds
Pharmaceutical industry