|Document ID (ISN)||100523|
|Convention or series no.
||Toxikologische Bewertung Nr.198
||Phenylisocyanat [in German]|
||Berufsgenossenschaft der chemischen Industrie, Postfach 10 14 80, 69004 Heidelberg, Germany, Jan. 1997. 35p. 40 ref.
||Workers exposed to isocyanates including phenyl isocyanate showed specific IgE for isocyanate-albumin conjugates. These workers also showed asthmatic symptoms. Animal experiments show the substance to be harmful upon oral administration. A low dermal toxicity and a high inhalation toxicity have been observed. Phenyl isocyanate induces severe skin and eye irritation and sensitization. No mutagenic or embryotoxic activity has been observed. A comparison of the toxic effects of 4-chlorophenyl isocyanate, phenyl isocyanate and 4-isopropylphenyl isocyanate in humans and animals is also presented. In humans, the only toxic effect described is an itchy erythema after repeated contact with chlorophenyl isocyanate.
||Germany; toxicity evaluation; pesticides; phenyl isocyanate
||toxic effects; literature survey; criteria document; animal experiments; irritants
||B - Chemical safety information sheets
|Country / State or Province||Germany|
||Toxic and dangerous substances
|Broad subject area(s)