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Document ID (ISN)100523
CIS number 02-1539
Year 1997
Convention or series no. Toxikologische Bewertung Nr.198
Title Phenyl isocyanate
Original title Phenylisocyanat [in German]
Bibliographic information Berufsgenossenschaft der chemischen Industrie, Postfach 10 14 80, 69004 Heidelberg, Germany, Jan. 1997. 35p. 40 ref.
Abstract Workers exposed to isocyanates including phenyl isocyanate showed specific IgE for isocyanate-albumin conjugates. These workers also showed asthmatic symptoms. Animal experiments show the substance to be harmful upon oral administration. A low dermal toxicity and a high inhalation toxicity have been observed. Phenyl isocyanate induces severe skin and eye irritation and sensitization. No mutagenic or embryotoxic activity has been observed. A comparison of the toxic effects of 4-chlorophenyl isocyanate, phenyl isocyanate and 4-isopropylphenyl isocyanate in humans and animals is also presented. In humans, the only toxic effect described is an itchy erythema after repeated contact with chlorophenyl isocyanate.
Descriptors (primary) Germany; toxicity evaluation; pesticides; phenyl isocyanate
Descriptors (secondary) toxic effects; literature survey; criteria document; animal experiments; irritants
Document type B - Chemical safety information sheets
Country / State or ProvinceGermany
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Isocyanates
Cyano compounds