ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)100516
CIS number 02-1823
ISSN - Serial title 0019-8366 - Industrial Health
Year 2001
Convention or series no.
Author(s) Nomiyama T., Uehara M., Miyauchi H., Imamiya S., Tanaka S., Seki Y.
Title Causal relationship between a case of severe hepatic dysfunction and low exposure concentrations of N,N-dimethylformamide in the synthetics industry
Bibliographic information Jan. 2001, Vol.39, No.1, p.33-36. 12 ref.
Abstract A 19-year-old man suffered hepatic dysfunction after five months of exposure to dimethylformamide (DMF) at his job in the synthetic resins industry. Medical examinations and laboratory data revealed elevated levels of AST (578IU/L), ALT (1193IU/L), and γ-GTP (107IU/L), no viral infection with HAV, HBV, or HCV, and no history or evidence of hepatic injury, although he did have a slight abdominal abnormality and swelling which was detected by palpation. His urinary methylformamide level, as a biological exposure index of DMF, was 42.8mg/L, indicating 10-30ppm of DMF exposure. After two months, the worker was reinstated in a workplace where environmental DMF concentrations were less than those in the former workplace. On the 18th day after his reinstatement, there was again evidence of hepatic dysfunction. After the second period of medication and one month of rest from work, he had fully recovered and was reinstated, but to a workshop without DMF exposure.
Descriptors (primary) plastics; hepatic diseases; dimethylformamide
Descriptors (secondary) case study; methylformamide; transaminases; exposure evaluation; long-term exposure; determination in urine; transfer to other work; subthreshold exposure; determination in blood; medical examinations; liver function tests
Document type D - Periodical articles
Country / State or ProvinceJapan
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Chemical safety
Browse category(ies) Amides
Liver diseases