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Document ID (ISN)100361
CIS number 02-1236
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2000
Convention or series no.
Author(s) Gibb H.J., Lees P.S.J., Pinsky P.F., Rooney B.C.
Title Lung cancer among workers in chromium chemical production
Bibliographic information Aug. 2000, Vol.38, No.2, p.115-126. Illus. 24 ref.
Abstract To assess the risk of lung cancer among chromate production workers, a cohort of 2,357 workers first employed between 1950 and 1974 at a chromate production plant was identified. Work histories of cohort members were compiled from the beginning of employment through 1985, the year the plant closed. Vital status of the workers was followed until 1992. Annual average exposure estimates, based on historical exposure measurements, were made for each job title in the plant for the years 1950-1985. These exposure estimates were used to calculate the cumulative hexavalent chromium exposure of each subject of the study population. Following closure of the plant, settled dust samples were collected, analysed, and used to estimate cumulative chromium exposure for each individual in the study cohort. It was found that cumulative hexavalent chromium exposure was associated with an increased lung cancer risk, while cumulative trivalent chromium exposure was not. The excess risk of lung cancer associated with cumulative hexavalent chromium exposure was not confounded by smoking status.
Descriptors (primary) lung cancer; hazard evaluation; chromium; chromium and compounds; dose-response relationship
Descriptors (secondary) smoking; exposure evaluation; chromates; dust analysis; chromium oxide; cohort study
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Inorganic substances
Risk evaluation